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2005 5
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2018 2
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Trends in Drug Resistance Prevalence, HIV-1 Variants and Clinical Status in HIV-1-infected Pediatric Population in Madrid: 1993 to 2015 Analysis.
Rojas Sánchez P, Domínguez S, Jiménez De Ory S, Prieto L, Rojo P, Mellado P, Navarro M, Delgado R, Ramos JT, Holguín Á; Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Pediatric Branch of the Spanish National AIDS Network (CoRISPe). Rojas Sánchez P, et al. Among authors: Holguin A. Pediatr Infect Dis J. 2018 Mar;37(3):e48-e57. doi: 10.1097/INF.0000000000001760. Pediatr Infect Dis J. 2018. PMID: 28991889
OBJECTIVE: We describe the temporal trends of HIV drug resistance mutations and the HIV-1 variants during 23 years (1993 to March 2016) in the Madrid cohort of HIV-infected children and adolescents. ...Non-B variants infected 14.5% of children and adol …
OBJECTIVE: We describe the temporal trends of HIV drug resistance mutations and the HIV-1 variants during 23 years (1993 to Ma …
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Rhee SY, Blanco JL, Jordan MR, Taylor J, Lemey P, Varghese V, Hamers RL, Bertagnolio S, Rinke de Wit TF, Aghokeng AF, Albert J, Avi R, Avila-Rios S, Bessong PO, Brooks JI, Boucher CA, Brumme ZL, Busch MP, Bussmann H, Chaix ML, Chin BS, D'Aquin TT, De Gascun CF, Derache A, Descamps D, Deshpande AK, Djoko CF, Eshleman SH, Fleury H, Frange P, Fujisaki S, Harrigan PR, Hattori J, Holguin A, Hunt GM, Ichimura H, Kaleebu P, Katzenstein D, Kiertiburanakul S, Kim JH, Kim SS, Li Y, Lutsar I, Morris L, Ndembi N, Ng KP, Paranjape RS, Peeters M, Poljak M, Price MA, Ragonnet-Cronin ML, Reyes-Terán G, Rolland M, Sirivichayakul S, Smith DM, Soares MA, Soriano VV, Ssemwanga D, Stanojevic M, Stefani MA, Sugiura W, Sungkanuparph S, Tanuri A, Tee KK, Truong HM, van de Vijver DA, Vidal N, Yang C, Yang R, Yebra G, Ioannidis JP, Vandamme AM, Shafer RW. Rhee SY, et al. Among authors: Holguin A. PLoS Med. 2015 Apr 7;12(4):e1001810. doi: 10.1371/journal.pmed.1001810. eCollection 2015 Apr. PLoS Med. 2015. PMID: 25849352 Free PMC article.
BACKGROUND: Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance te …
BACKGROUND: Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing …
Relevance of cutoff on a 4th generation ELISA performance in the false positive rate during HIV diagnostic in a low HIV prevalence setting.
Chacón L, Mateos ML, Holguín Á. Chacón L, et al. Among authors: Holguin A. J Clin Virol. 2017 Jul;92:11-13. doi: 10.1016/j.jcv.2017.04.014. Epub 2017 Apr 26. J Clin Virol. 2017. PMID: 28501753
All 19 samples with S/CO ≤10 were false positives and all 220 with S/CO>50 true HIV-positives. The optimal S/CO cutoff value provided by ROC curves was 32.7. ...CONCLUSIONS: We show that very low S/CO values during HIV-1 screening usin …
All 19 samples with S/CO ≤10 were false positives and all 220 with S/CO>50 true HIV-positives. The optimal S/ …
Phylogenetic and demographic characterization of HIV-1 transmission in Madrid, Spain.
Yebra G, Holguín A, Pillay D, Hué S. Yebra G, et al. Among authors: Holguin A. Infect Genet Evol. 2013 Mar;14:232-9. doi: 10.1016/j.meegid.2012.12.006. Epub 2013 Jan 2. Infect Genet Evol. 2013. PMID: 23291408
The Community of Madrid represents a challenge for the control of HIV epidemic in Spain given its high HIV prevalence and increasing proportion of immigrant people among HIV-infected population. ...CONCLUSIONS: One out of five HIV-infected patie …
The Community of Madrid represents a challenge for the control of HIV epidemic in Spain given its high HIV prevalence a …
Molecular surveillance of HIV-1 in Madrid, Spain: a phylogeographic analysis.
González-Alba JM, Holguín A, Garcia R, García-Bujalance S, Alonso R, Suárez A, Delgado R, Cardeñoso L, González R, García-Bermejo I, Portero F, de Mendoza C, González-Candelas F, Galán JC. González-Alba JM, et al. Among authors: Holguin A. J Virol. 2011 Oct;85(20):10755-63. doi: 10.1128/JVI.00454-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795343 Free PMC article.
In recent years, Spain has become one of Europe's main destinations for immigrants and one of the western European countries with the highest rates of HIV-positive patients. Using a phylogeographic approach, we have analyzed the relationship between HIV-1 var …
In recent years, Spain has become one of Europe's main destinations for immigrants and one of the western European countries with the …
Impact of lopinavir-ritonavir exposure in HIV-1 infected children and adolescents in Madrid, Spain during 2000-2014.
Rojas Sánchez P, Prieto L, Jiménez De Ory S, Fernández Cooke E, Navarro ML, Ramos JT, Holguín Á; Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Network (CoRISPe). Rojas Sánchez P, et al. Among authors: Holguin A. PLoS One. 2017 Mar 28;12(3):e0173168. doi: 10.1371/journal.pone.0173168. eCollection 2017. PLoS One. 2017. PMID: 28350802 Free PMC article.
This study describes the virological outcome of the HIV-1-infected paediatric population exposed to LPV/r during 15 years in Spain. METHODOLOGY: Patients from the Madrid Cohort of HIV-1-infected-children and adolescents exposed to LPV/r as different line ther …
This study describes the virological outcome of the HIV-1-infected paediatric population exposed to LPV/r during 15 years in Spain. M …
Description and consequences of prescribing off-label antiretrovirals in the Madrid Cohort of HIV-infected children over a quarter of a century (1988-2012).
Fernández-Cooke E, Rojas P, Holguin A, Tomé MI, Jimenez de Ory S, Mellado MJ, Navarro ML, Rojo P, Ramos JT. Fernández-Cooke E, et al. Among authors: Holguin A. Antivir Ther. 2016;21(1):65-70. doi: 10.3851/IMP2973. Epub 2015 Jun 16. Antivir Ther. 2016. PMID: 26079937 Clinical Trial.
We measured the extent and consequences of off-label antiretroviral (ARV) use in an HIV-infected paediatric cohort. METHODS: In this multicentre cohort study involving 318 HIV-infected children and adolescents from the Madrid Cohort, all off-label prescriptio …
We measured the extent and consequences of off-label antiretroviral (ARV) use in an HIV-infected paediatric cohort. METHODS: In this …
Clinical and virologic follow-up in perinatally HIV-1-infected children and adolescents in Madrid with triple-class antiretroviral drug-resistant viruses.
Rojas Sánchez P, de Mulder M, Fernandez-Cooke E, Prieto L, Rojo P, Jiménez de Ory S, José Mellado M, Navarro M, Tomas Ramos J, Holguín Á; Madrid Cohort of HIV-Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Network (CoRISPe). Rojas Sánchez P, et al. Among authors: Holguin A. Clin Microbiol Infect. 2015 Jun;21(6):605.e1-9. doi: 10.1016/j.cmi.2015.02.003. Epub 2015 Feb 11. Clin Microbiol Infect. 2015. PMID: 25680310 Free article.
We report the virologic and clinical follow-up of the Madrid cohort of perinatally HIV-infected children and adolescents after the selection of triple-class drug-resistant mutations (TC-DRM). ...These data will help to improve the clinical management of HIV-i …
We report the virologic and clinical follow-up of the Madrid cohort of perinatally HIV-infected children and adolescents after …
Utility Of POC Xpert HIV-1 Tests For Detection-Quantification Of Complex HIV Recombinants Using Dried Blood Spots From Kinshasa, D. R. Congo.
Rubio-Garrido M, Ndarabu A, Reina G, Barquín D, Fernández-Alonso M, Carlos S, Holguín Á. Rubio-Garrido M, et al. Among authors: Holguin A. Sci Rep. 2019 Apr 5;9(1):5679. doi: 10.1038/s41598-019-41963-y. Sci Rep. 2019. PMID: 30952893 Free PMC article.
We compared viraemia with Cepheid-POC-Xpert-HIV-1VL and the non-POC-COBAS(®)AmpliPrep/COBAS(®)TaqMan(®)HIV-1-Testv2 in all HIV+, carrying 72.4%/7.2% HIV-1 unique/complex recombinant forms (URF/CRF). HIV-1 infection was confirmed in 14 HIV
We compared viraemia with Cepheid-POC-Xpert-HIV-1VL and the non-POC-COBAS(®)AmpliPrep/COBAS(®)TaqMan(®)HIV-1-Testv2 in all …
Drug resistance prevalence and HIV-1 variant characterization in the naive and pretreated HIV-1-infected paediatric population in Madrid, Spain.
de Mulder M, Yebra G, Martín L, Prieto L, Mellado MJ, Rojo P, Muñoz-Fernández MÁ, Jiménez de Ory S, Ramos JT, Holguín A; Madrid cohort of HIV-infected children. de Mulder M, et al. Among authors: Holguin A. J Antimicrob Chemother. 2011 Oct;66(10):2362-71. doi: 10.1093/jac/dkr305. Epub 2011 Aug 2. J Antimicrob Chemother. 2011. PMID: 21810838
HIV-1 variants and drug resistance mutations were identified in HIV-infected children from Madrid, Spain. METHODS: Patients from the Madrid cohort of HIV-infected children (1993-2009) with available pol sequences or infected samples stored at th
HIV-1 variants and drug resistance mutations were identified in HIV-infected children from Madrid, Spain. METHODS: Pati
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