Holien JK - Search Results

1

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J. Nachbur U, et al. Among authors: holien jk. Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442. Nat Commun. 2015. PMID: 25778803 Free article.

2

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation.

Hurt AC, Holien JK, Parker M, Kelso A, Barr IG. Hurt AC, et al. Among authors: holien jk. J Virol. 2009 Oct;83(20):10366-73. doi: 10.1128/JVI.01200-09. Epub 2009 Jul 29. J Virol. 2009. PMID: 19641000 Free PMC article.

3

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

Hurt AC, Holien JK, Parker MW, Barr IG. Hurt AC, et al. Among authors: holien jk. Drugs. 2009;69(18):2523-31. doi: 10.2165/11531450-000000000-00000. Drugs. 2009. PMID: 19943705

4

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.

Albiston AL, Pham V, Ye S, Ng L, Lew RA, Thompson PE, Holien JK, Morton CJ, Parker MW, Chai SY. Albiston AL, et al. Among authors: holien jk. Mol Pharmacol. 2010 Oct;78(4):600-7. doi: 10.1124/mol.110.065458. Epub 2010 Jul 13. Mol Pharmacol. 2010. PMID: 20628006

5

Direct involvement of the TEN domain at the active site of human telomerase.

Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM. Jurczyluk J, et al. Among authors: holien jk. Nucleic Acids Res. 2011 Mar;39(5):1774-88. doi: 10.1093/nar/gkq1083. Epub 2010 Nov 3. Nucleic Acids Res. 2011. PMID: 21051362 Free PMC article.

6

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers.

Albiston AL, Diwakarla S, Fernando RN, Mountford SJ, Yeatman HR, Morgan B, Pham V, Holien JK, Parker MW, Thompson PE, Chai SY. Albiston AL, et al. Among authors: holien jk. Br J Pharmacol. 2011 Sep;164(1):37-47. doi: 10.1111/j.1476-5381.2011.01402.x. Br J Pharmacol. 2011. PMID: 21470200 Free PMC article. Review.

7

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia.

Topcic D, Kim W, Holien JK, Jia F, Armstrong PC, Hohmann JD, Straub A, Krippner G, Haller CA, Domeij H, Hagemeyer CE, Parker MW, Chaikof EL, Peter K. Topcic D, et al. Among authors: holien jk. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2015-23. doi: 10.1161/ATVBAHA.111.226241. Epub 2011 Jun 9. Arterioscler Thromb Vasc Biol. 2011. PMID: 21659646

8

Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.

Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S. Gazina EV, et al. Among authors: holien jk. J Virol. 2011 Oct;85(19):10364-74. doi: 10.1128/JVI.05022-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795353 Free PMC article.

9

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis JL, Feil SC, Hancock NC, Zheng Z, Ng HL, Morton CJ, Holien JK, Ho PW, Frazzetto MM, Jennings IG, Manallack DT, Martin TJ, Thompson PE, Parker MW. Nankervis JL, et al. Among authors: holien jk. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22030030

10

Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.

Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW. Feil SC, et al. Among authors: holien jk. Structure. 2012 Feb 8;20(2):248-58. doi: 10.1016/j.str.2011.11.017. Structure. 2012. PMID: 22325774 Free PMC article.

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