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More than a feeling: discovering, understanding, and influencing mechanosensing pathways.
Holle AW, Engler AJ. Holle AW, et al. Curr Opin Biotechnol. 2011 Oct;22(5):648-54. doi: 10.1016/j.copbio.2011.04.007. Epub 2011 Apr 30. Curr Opin Biotechnol. 2011. PMID: 21536426 Free PMC article.
Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.
Hadden WJ, Young JL, Holle AW, McFetridge ML, Kim DY, Wijesinghe P, Taylor-Weiner H, Wen JH, Lee AR, Bieback K, Vo BN, Sampson DD, Kennedy BF, Spatz JP, Engler AJ, Choi YS. Hadden WJ, et al. Among authors: holle aw. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5647-5652. doi: 10.1073/pnas.1618239114. Epub 2017 May 15. Proc Natl Acad Sci U S A. 2017. PMID: 28507138 Free PMC article.
High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.
Holle AW, McIntyre AJ, Kehe J, Wijesekara P, Young JL, Vincent LG, Engler AJ. Holle AW, et al. Integr Biol (Camb). 2016 Oct 10;8(10):1049-1058. doi: 10.1039/c6ib00076b. Integr Biol (Camb). 2016. PMID: 27723854 Free PMC article.
In situ mechanotransduction via vinculin regulates stem cell differentiation.
Holle AW, Tang X, Vijayraghavan D, Vincent LG, Fuhrmann A, Choi YS, del Álamo JC, Engler AJ. Holle AW, et al. Stem Cells. 2013 Nov;31(11):2467-77. doi: 10.1002/stem.1490. Stem Cells. 2013. PMID: 23897765 Free PMC article.
Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.
Holle AW, Young JL, Van Vliet KJ, Kamm RD, Discher D, Janmey P, Spatz JP, Saif T. Holle AW, et al. Nano Lett. 2018 Jan 10;18(1):1-8. doi: 10.1021/acs.nanolett.7b04982. Epub 2017 Dec 6. Nano Lett. 2018. PMID: 29178811 Free PMC article.
Cancer Cells Invade Confined Microchannels via a Self-Directed Mesenchymal-to-Amoeboid Transition.
Holle AW, Govindan Kutty Devi N, Clar K, Fan A, Saif T, Kemkemer R, Spatz JP. Holle AW, et al. Nano Lett. 2019 Apr 10;19(4):2280-2290. doi: 10.1021/acs.nanolett.8b04720. Epub 2019 Mar 8. Nano Lett. 2019. PMID: 30775927 Free PMC article.
In vitro cancer cell-ECM interactions inform in vivo cancer treatment.
Holle AW, Young JL, Spatz JP. Holle AW, et al. Adv Drug Deliv Rev. 2016 Feb 1;97:270-9. doi: 10.1016/j.addr.2015.10.007. Epub 2015 Oct 17. Adv Drug Deliv Rev. 2016. PMID: 26485156 Review.
Nanoscale and mechanical properties of the physiological cell-ECM microenvironment.
Young JL, Holle AW, Spatz JP. Young JL, et al. Exp Cell Res. 2016 Apr 10;343(1):3-6. doi: 10.1016/j.yexcr.2015.10.037. Epub 2015 Oct 30. Exp Cell Res. 2016. PMID: 26524509 Review.
Initial contact guidance during cell spreading is contractility-independent.
Sales A, Holle AW, Kemkemer R. Sales A, et al. Among authors: holle aw. Soft Matter. 2017 Aug 2;13(30):5158-5167. doi: 10.1039/c6sm02685k. Soft Matter. 2017. PMID: 28664962
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