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Grapefruit juice inhibits the metabolic activation of clopidogrel.
Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Holmberg MT, et al. Clin Pharmacol Ther. 2014 Mar;95(3):307-13. doi: 10.1038/clpt.2013.192. Epub 2013 Sep 25. Clin Pharmacol Ther. 2014. PMID: 24067745 Clinical Trial.
Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.
Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT. Kahma H, et al. Among authors: holmberg mt. Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14. Drug Metab Dispos. 2018. PMID: 29138287
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.
Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M. Neuvonen M, et al. Among authors: holmberg mt. Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17. Basic Clin Pharmacol Toxicol. 2018. PMID: 28990360 Free article.
Effect of grapefruit juice on the bioactivation of prasugrel.
Holmberg MT, Tornio A, Hyvärinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Holmberg MT, et al. Br J Clin Pharmacol. 2015 Jul;80(1):139-45. doi: 10.1111/bcp.12581. Epub 2015 Jun 1. Br J Clin Pharmacol. 2015. PMID: 25557052 Free PMC article. Clinical Trial.
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