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Page 1
Acute Stress Increases Striatal Connectivity With Cortical Regions Enriched for μ and κ Opioid Receptors.
Zhukovsky P, Ironside M, Duda JM, Moser AD, Null KE, Dhaynaut M, Normandin M, Guehl NJ, El Fakhri G, Alexander M, Holsen LM, Misra M, Narendran R, Hoye JM, Morris ED, Esfand SM, Goldstein JM, Pizzagalli DA. Zhukovsky P, et al. Among authors: holsen lm. Biol Psychiatry. 2024 Nov 1;96(9):717-726. doi: 10.1016/j.biopsych.2024.02.005. Epub 2024 Feb 22. Biol Psychiatry. 2024. PMID: 38395372
Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling.
Breithaupt L, Holsen LM, Ji C, Hu J, Petterway F, Rosa-Caldwell M, Nilsson IAK, Thomas JJ, Williams KA, Boutin R, Slattery M, Bulik CM, Arnold SE, Lawson EA, Misra M, Eddy KT. Breithaupt L, et al. Among authors: holsen lm. Biol Psychiatry Glob Open Sci. 2024 May 8;4(5):100332. doi: 10.1016/j.bpsgos.2024.100332. eCollection 2024 Sep. Biol Psychiatry Glob Open Sci. 2024. PMID: 38989135 Free PMC article.
Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects.
Ironside M, Duda JM, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Chen X, Nickerson LD, Null KE, Esfand SM, Alexander MM, Crowley DJ, Lauze M, Misra M, Goldstein JM, Pizzagalli DA. Ironside M, et al. Among authors: holsen lm. Am J Psychiatry. 2024 Jul 1;181(7):639-650. doi: 10.1176/appi.ajp.20230382. Epub 2024 Apr 30. Am J Psychiatry. 2024. PMID: 38685857
Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression.
Duda JM, Moser AD, Ironside M, Null KE, Holsen LM, Zuo CS, Du F, Esfand SM, Chen X, Perlo S, Richards CE, Lobien R, Alexander M, Misra M, Goldstein JM, Pizzagalli DA. Duda JM, et al. Among authors: holsen lm. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jun;9(6):606-615. doi: 10.1016/j.bpsc.2024.02.009. Epub 2024 Feb 28. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024. PMID: 38417785
Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin.
Wronski ML, Bernardoni F, Bahnsen K, Seidel M, Arold D, Doose A, Steinhäuser JL, Borucki K, Breithaupt L, Lawson EA, Holsen LM, Weidner K, Roessner V, King JA, Plessow F, Ehrlich S. Wronski ML, et al. Among authors: holsen lm. J Am Acad Child Adolesc Psychiatry. 2024 Jun;63(6):624-639. doi: 10.1016/j.jaac.2023.08.015. Epub 2023 Oct 3. J Am Acad Child Adolesc Psychiatry. 2024. PMID: 37797814
Intranasal Oxytocin for Obesity.
Plessow F, Kerem L, Wronski ML, Asanza E, O'Donoghue ML, Stanford FC, Eddy KT, Holmes TM, Misra M, Thomas JJ, Galbiati F, Muhammed M, Sella AC, Hauser K, Smith SE, Holman K, Gydus J, Aulinas A, Vangel M, Healy B, Kheterpal A, Torriani M, Holsen LM, Bredella MA, Lawson EA. Plessow F, et al. Among authors: holsen lm. NEJM Evid. 2024 May;3(5):EVIDoa2300349. doi: 10.1056/EVIDoa2300349. Epub 2024 Apr 23. NEJM Evid. 2024. PMID: 38815173 Clinical Trial.
Key secondary end points included change in body composition (total fat mass [g], abdominal visceral adipose tissue [cm(2)], and liver fat fraction [proportion; range, 0 to 1; higher values indicate a higher proportion of fat]), and resting energy expenditure (kcal/day; adjusted …
Key secondary end points included change in body composition (total fat mass [g], abdominal visceral adipose tissue [cm(2)], and liver fat f …
Corrigendum to "A randomized, double-blind, placebo-controlled clinical trial of 8-week intranasal oxytocin administration in adults with obesity: Rationale, study design, and methods" [Contemporary Clinical Trials 122 (2022) 1-11/106909].
Wronski ML, Plessow F, Kerem L, Asanza E, O'Donoghue ML, Stanford FC, Bredella MA, Torriani M, Soukas AA, Kheterpal A, Eddy KT, Holmes TM, Deckersbach T, Vangel M, Holsen LM, Lawson EA. Wronski ML, et al. Among authors: holsen lm. Contemp Clin Trials. 2024 May;140:107511. doi: 10.1016/j.cct.2024.107511. Epub 2024 Mar 23. Contemp Clin Trials. 2024. PMID: 38522969 Free PMC article. No abstract available.
Explicating the role of amygdala substructure alterations in the link between hypoleptinemia and rumination in anorexia nervosa.
Wronski ML, Hohnemann C, Bernardoni F, Bahnsen K, Doose A, Arold D, Borucki K, Holsen LM, Lawson EA, Plessow F, Weidner K, Roessner V, Diestel S, King JA, Seidel M, Ehrlich S. Wronski ML, et al. Among authors: holsen lm. Acta Psychiatr Scand. 2023 Oct;148(4):368-381. doi: 10.1111/acps.13607. Epub 2023 Sep 8. Acta Psychiatr Scand. 2023. PMID: 37688292
The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.
Becetti I, Bwenyi EL, de Araujo IE, Ard J, Cryan JF, Farooqi IS, Ferrario CR, Gluck ME, Holsen LM, Kenny PJ, Lawson EA, Lowell BB, Schur EA, Stanley TL, Tavakkoli A, Grinspoon SK, Singhal V. Becetti I, et al. Among authors: holsen lm. Am J Clin Nutr. 2023 Jul;118(1):314-328. doi: 10.1016/j.ajcnut.2023.05.003. Epub 2023 May 4. Am J Clin Nutr. 2023. PMID: 37149092 Free PMC article.
The purpose of this article is to summarize the key findings presented in June 2022 at the 23rd annual Harvard Nutrition Obesity Symposium entitled "The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets." Findings presented at the symposium, sp …
The purpose of this article is to summarize the key findings presented in June 2022 at the 23rd annual Harvard Nutrition Obesity Symp …
Neural response to stress differs by sex in young adulthood.
Cohen JE, Holsen LM, Ironside M, Moser AD, Duda JM, Null KE, Perlo S, Richards CE, Nascimento NF, Du F, Zuo C, Misra M, Pizzagalli DA, Goldstein JM. Cohen JE, et al. Among authors: holsen lm. Psychiatry Res Neuroimaging. 2023 Jul;332:111646. doi: 10.1016/j.pscychresns.2023.111646. Epub 2023 Apr 25. Psychiatry Res Neuroimaging. 2023. PMID: 37146439 Free PMC article.
Results demonstrated significant sex differences in brain activity with women exhibiting increased activation in regions that inhibit arousal compared to men during the stress paradigm. Women had increased connectivity among stress circuitry regions and default mode …
Results demonstrated significant sex differences in brain activity with women exhibiting increased activation in regions that inhibit …
Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls.
Eddy KT, Plessow F, Breithaupt L, Becker KR, Slattery M, Mancuso CJ, Izquierdo AM, Van De Water AL, Kahn DL, Dreier MJ, Ebrahimi S, Deckersbach T, Thomas JJ, Holsen LM, Misra M, Lawson EA. Eddy KT, et al. Among authors: holsen lm. Transl Psychiatry. 2023 Jun 23;13(1):220. doi: 10.1038/s41398-023-02494-3. Transl Psychiatry. 2023. PMID: 37353543 Free PMC article.
Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa.
Kim YR, Lauze MS, Slattery M, Perlis RH, Holsen LM, Breithaupt L, Stern CM, Fava M, Thomas JJ, Lawson EA, Misra M, Eddy KT. Kim YR, et al. Among authors: holsen lm. JAMA Netw Open. 2023 Mar 1;6(3):e234625. doi: 10.1001/jamanetworkopen.2023.4625. JAMA Netw Open. 2023. PMID: 36961462 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study was conducted between April 1, 2014, and March 31, 2020, in the US. Girls and women aged 10 to 22 years were recruited from the greater Boston area from community and area treatment centers, enrolled, and fol …
DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study was conducted between April 1, 2014, and March 31, 2020, in the US. Girls a …
A randomized, double-blind, placebo-controlled clinical trial of 8-week intranasal oxytocin administration in adults with obesity: Rationale, study design, and methods.
Wronski ML, Plessow F, Kerem L, Asanza E, O'Donoghue ML, Stanford FC, Bredella MA, Torriani M, Soukas AA, Kheterpal A, Eddy KT, Holmes TM, Deckersbach T, Vangel M, Holsen LM, Lawson EA. Wronski ML, et al. Among authors: holsen lm. Contemp Clin Trials. 2022 Nov;122:106909. doi: 10.1016/j.cct.2022.106909. Epub 2022 Sep 7. Contemp Clin Trials. 2022. PMID: 36087842 Free PMC article. Clinical Trial.
Perceived Stress, Cortical GABA, and Functional Connectivity Correlates: A Hypothesis-Generating Preliminary Study.
Busler JN, Coello E, Liao H, Taylor J, Zhao W, Holsen LM, Lin AP, Mahon PB. Busler JN, et al. Among authors: holsen lm. Front Psychiatry. 2022 Mar 8;13:802449. doi: 10.3389/fpsyt.2022.802449. eCollection 2022. Front Psychiatry. 2022. PMID: 35350427 Free PMC article.
Therefore, the current study examined the association of perceived stress, via the Perceived Stress Scale (PSS), with prefrontal GABA levels and corresponding resting state functional connectivity (RSFC) alterations. Twelve women and five men, ages 35-61, participated. MR …
Therefore, the current study examined the association of perceived stress, via the Perceived Stress Scale (PSS), with prefrontal GABA levels …
Reverse-translational identification of a cerebellar satiation network.
Low AYT, Goldstein N, Gaunt JR, Huang KP, Zainolabidin N, Yip AKK, Carty JRE, Choi JY, Miller AM, Ho HST, Lenherr C, Baltar N, Azim E, Sessions OM, Ch'ng TH, Bruce AS, Martin LE, Halko MA, Brady RO Jr, Holsen LM, Alhadeff AL, Chen AI, Betley JN. Low AYT, et al. Among authors: holsen lm. Nature. 2021 Dec;600(7888):269-273. doi: 10.1038/s41586-021-04143-5. Epub 2021 Nov 17. Nature. 2021. PMID: 34789878 Free PMC article.
Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation.
Ironside M, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Duda JM, Chen X, Nickerson LD, Null KE, Nascimento N, Crowley DJ, Misra M, Goldstein JM, Pizzagalli DA. Ironside M, et al. Among authors: holsen lm. Neuropsychopharmacology. 2021 Nov;46(12):2188-2196. doi: 10.1038/s41386-021-01127-x. Epub 2021 Aug 6. Neuropsychopharmacology. 2021. PMID: 34363015 Free PMC article.
Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.
Holsen LM, Huang G, Cherkerzian S, Aroner S, Loucks EB, Buka S, Handa RJ, Goldstein JM. Holsen LM, et al. J Womens Health (Larchmt). 2021 Sep;30(9):1303-1312. doi: 10.1089/jwh.2020.8467. Epub 2021 Feb 2. J Womens Health (Larchmt). 2021. PMID: 33534642 Free PMC article.
Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. ...Results: Parti …
Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity ap …
Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults.
Holsen LM, Hoge WS, Lennerz BS, Cerit H, Hye T, Moondra P, Goldstein JM, Ebbeling CB, Ludwig DS. Holsen LM, et al. J Nutr. 2021 Aug 7;151(8):2465-2476. doi: 10.1093/jn/nxab090. J Nutr. 2021. PMID: 33852013 Free PMC article. Clinical Trial.
METHODS: In conjunction with a randomized controlled feeding trial, we investigated the effects of weight-loss maintenance diets varying in carbohydrate content [high, 60% of total energy: n = 20; 6 men/14 women; mean age: 32.5 y; mean BMI (in kg/m 2): 27.4; moderate, 40% …
METHODS: In conjunction with a randomized controlled feeding trial, we investigated the effects of weight-loss maintenance diets varying in …
Developmental stage-dependent relationships between ghrelin levels and hippocampal white matter connections in low-weight anorexia nervosa and atypical anorexia nervosa.
Breithaupt L, Chunga-Iturry N, Lyall AE, Cetin-Karayumak S, Becker KR, Thomas JJ, Slattery M, Makris N, Plessow F, Pasternak O, Holsen LM, Kubicki M, Misra M, Lawson EA, Eddy KT. Breithaupt L, et al. Among authors: holsen lm. Psychoneuroendocrinology. 2020 Sep;119:104722. doi: 10.1016/j.psyneuen.2020.104722. Epub 2020 May 23. Psychoneuroendocrinology. 2020. PMID: 32512249 Free PMC article.
Impact of sex and depressed mood on the central regulation of cardiac autonomic function.
Garcia RG, Mareckova K, Holsen LM, Cohen JE, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Garcia RG, et al. Among authors: holsen lm. Neuropsychopharmacology. 2020 Jul;45(8):1280-1288. doi: 10.1038/s41386-020-0651-x. Epub 2020 Mar 9. Neuropsychopharmacology. 2020. PMID: 32152473 Free PMC article.
Associations between changes in activity and functional connectivity of the stress response circuitry and variations in cardiovagal activity [normalized high frequency power of heart rate variability (HFn)] were evaluated using GLM analyses, including interactions with depressed …
Associations between changes in activity and functional connectivity of the stress response circuitry and variations in cardiovagal activity …
Divergent associations between ghrelin and neural responsivity to palatable food in hyperphagic and hypophagic depression.
Cerit H, Christensen K, Moondra P, Klibanski A, Goldstein JM, Holsen LM. Cerit H, et al. Among authors: holsen lm. J Affect Disord. 2019 Jan 1;242:29-38. doi: 10.1016/j.jad.2018.07.088. Epub 2018 Aug 18. J Affect Disord. 2019. PMID: 30170236 Free PMC article.
We aimed to investigate the relationship between acylated ghrelin levels and the neural response to food stimuli in individuals with hyperphagic and hypophagic MDD in remission. METHODS: Women with hyperphagic MDD (n = 10), hypophagic MDD (n = 18), and healthy controls (HC …
We aimed to investigate the relationship between acylated ghrelin levels and the neural response to food stimuli in individuals with hyperph …
Neural predictors of 12-month weight loss outcomes following bariatric surgery.
Holsen LM, Davidson P, Cerit H, Hye T, Moondra P, Haimovici F, Sogg S, Shikora S, Goldstein JM, Evins AE, Stoeckel LE. Holsen LM, et al. Int J Obes (Lond). 2018 Apr;42(4):785-793. doi: 10.1038/ijo.2017.190. Epub 2017 Aug 14. Int J Obes (Lond). 2018. PMID: 28894291 Free PMC article.
Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.
Plessow F, Marengi DA, Perry SK, Felicione JM, Franklin R, Holmes TM, Holsen LM, Makris N, Deckersbach T, Lawson EA. Plessow F, et al. Among authors: holsen lm. Neuropsychopharmacology. 2018 Feb;43(3):638-645. doi: 10.1038/npp.2017.226. Epub 2017 Sep 20. Neuropsychopharmacology. 2018. PMID: 28930284 Free PMC article. Clinical Trial.
Reward Capacity Predicts Leptin Dynamics During Laboratory-Controlled Eating in Women as a Function of Body Mass Index.
Holsen LM, Jackson B. Holsen LM, et al. Obesity (Silver Spring). 2017 Sep;25(9):1564-1568. doi: 10.1002/oby.21930. Epub 2017 Jul 19. Obesity (Silver Spring). 2017. PMID: 28722317 Free PMC article.
METHODS: In this cross-sectional study of 75 women (42 with BMIs in the lean range and 33 with BMIs in the obesity range), serum leptin before and after meal consumption was measured. ...CONCLUSIONS: In this sample, a robust negative association between reward capacity and …
METHODS: In this cross-sectional study of 75 women (42 with BMIs in the lean range and 33 with BMIs in the obesity range), serum lept …
Child Maltreatment's Heavy Toll: The Need for Trauma-Informed Obesity Prevention.
Mason SM, Bryn Austin S, Bakalar JL, Boynton-Jarrett R, Field AE, Gooding HC, Holsen LM, Jackson B, Neumark-Sztainer D, Sanchez M, Sogg S, Tanofsky-Kraff M, Rich-Edwards JW. Mason SM, et al. Among authors: holsen lm. Am J Prev Med. 2016 May;50(5):646-649. doi: 10.1016/j.amepre.2015.11.004. Epub 2015 Dec 11. Am J Prev Med. 2016. PMID: 26689978 Free PMC article. No abstract available.
Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses.
Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Goldstein JM, et al. Among authors: holsen lm. Psychiatry Res. 2015 Jun 30;232(3):226-36. doi: 10.1016/j.pscychresns.2015.03.006. Epub 2015 Mar 31. Psychiatry Res. 2015. PMID: 25914141 Free PMC article.
We predicted abnormal steroid hormone levels in PSY would be associated with sex differences in hyperactivity in HYPO, AMYG, and HIPP, and hypoactivity in PFC and ACC, with more severe deficits in men. We studied 32 PSY cases (50.0% women) and 39 controls (43.6% women
We predicted abnormal steroid hormone levels in PSY would be associated with sex differences in hyperactivity in HYPO, AMYG, and HIPP, and h …
17beta-estradiol differentially regulates stress circuitry activity in healthy and depressed women.
Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. Jacobs EG, et al. Among authors: holsen lm. Neuropsychopharmacology. 2015 Feb;40(3):566-76. doi: 10.1038/npp.2014.203. Epub 2014 Aug 12. Neuropsychopharmacology. 2015. PMID: 25113601 Free PMC article.
Capitalizing on the endogenous fluctuation in E2 during the menstrual cycle, we conducted a within-person repeated-measures functional neuroimaging study in which 15 women with recurrent MDD, in remission, and 15 healthy control women underwent hormonal evaluations, …
Capitalizing on the endogenous fluctuation in E2 during the menstrual cycle, we conducted a within-person repeated-measures functional neuro …
Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa.
Holsen LM, Lawson EA, Christensen K, Klibanski A, Goldstein JM. Holsen LM, et al. Psychiatry Res. 2014 Aug 30;223(2):94-103. doi: 10.1016/j.pscychresns.2014.04.015. Epub 2014 May 6. Psychiatry Res. 2014. PMID: 24862390 Free PMC article.
In a cross-sectional design, we studied 13 women with active anorexia nervosa (AN), 9 women weight-recovered from AN (AN-WR), and 12 healthy-weight control women using a food cue functional magnetic resonance imaging paradigm, with assessment of fasting level …
In a cross-sectional design, we studied 13 women with active anorexia nervosa (AN), 9 women weight-recovered from AN (AN-WR), …
Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa.
Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, Goldstein JM, Klibanski A. Lawson EA, et al. Among authors: holsen lm. Eur J Endocrinol. 2013 Oct 1;169(5):639-47. doi: 10.1530/EJE-13-0433. Print 2013 Nov. Eur J Endocrinol. 2013. PMID: 23946275 Free PMC article.
Using a food-related functional magnetic resonance imaging (fMRI) paradigm, we have demonstrated hypoactivation of brain regions involved in food motivation in women with AN, even after weight recovery. The relationship between hypothalamic-pituitary-adrenal (HPA) axis dys …
Using a food-related functional magnetic resonance imaging (fMRI) paradigm, we have demonstrated hypoactivation of brain regions involved in …
HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression.
Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian S, Buka S, Goldstein JM. Holsen LM, et al. Neuroscience. 2013 Oct 10;250:733-42. doi: 10.1016/j.neuroscience.2013.07.042. Epub 2013 Jul 25. Neuroscience. 2013. PMID: 23891965 Free PMC article.
The current study addresses this gap by investigating neural responses to a mild visual stress challenge with real-time assessment of adrenal hormones in women with MDD in remission and controls. Fifteen women with recurrent MDD in remission (rMDD) and 15 healthy co …
The current study addresses this gap by investigating neural responses to a mild visual stress challenge with real-time assessment of adrena …
Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa.
Lawson EA, Holsen LM, Santin M, Meenaghan E, Eddy KT, Becker AE, Herzog DB, Goldstein JM, Klibanski A. Lawson EA, et al. Among authors: holsen lm. J Clin Endocrinol Metab. 2012 Oct;97(10):E1898-908. doi: 10.1210/jc.2012-1702. Epub 2012 Aug 7. J Clin Endocrinol Metab. 2012. PMID: 22872688 Free PMC article.
OBJECTIVE: The objective of the study was to determine whether the oxytocin response to feeding in anorexia differs from healthy women and to establish the relationship between oxytocin secretion and disordered eating psychopathology and food-motivation neurocircuitry. ... …
OBJECTIVE: The objective of the study was to determine whether the oxytocin response to feeding in anorexia differs from healthy women
Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa.
Holsen LM, Lawson EA, Blum J, Ko E, Makris N, Fazeli PK, Klibanski A, Goldstein JM. Holsen LM, et al. J Psychiatry Neurosci. 2012 Sep;37(5):322-32. doi: 10.1503/jpn.110156. J Psychiatry Neurosci. 2012. PMID: 22498079 Free PMC article.
RESULTS: We enrolled 12 women with active disease, 10 weight-restored women with anorexia nervosa and 11 controls in our study. ...Postmeal, hypoactivation in the anterior insula persisted in women with active disease. Percent signal change in the anterior in …
RESULTS: We enrolled 12 women with active disease, 10 weight-restored women with anorexia nervosa and 11 controls in our study …
Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression.
Holsen LM, Spaeth SB, Lee JH, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Goldstein JM. Holsen LM, et al. J Affect Disord. 2011 Jun;131(1-3):379-87. doi: 10.1016/j.jad.2010.11.024. Epub 2010 Dec 22. J Affect Disord. 2011. PMID: 21183223 Free PMC article.
BACKGROUND: Women have approximately twice the risk of major depressive disorder (MDD) than men, yet this difference remains largely unexplained. ...CONCLUSIONS: Hypoactivation of the stress response circuitry in MDD women is associated with dysregulation of the HPG …
BACKGROUND: Women have approximately twice the risk of major depressive disorder (MDD) than men, yet this difference remains largely …