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Contra-indications to metformin therapy are largely disregarded.
Holstein A, Nahrwold D, Hinze S, Egberts EH. Holstein A, et al. Diabet Med. 1999 Aug;16(8):692-6. doi: 10.1046/j.1464-5491.1999.00115.x. Diabet Med. 1999. PMID: 10477216
METHODS: A cross-sectional analysis of 308 consecutive Type 2 diabetic patients (mean age 66+/-11.3 years) previously treated with metformin on an outpatient basis and admitted to a German general hospital during the period from 1 January 1995 to 31 May 1998 because …
METHODS: A cross-sectional analysis of 308 consecutive Type 2 diabetic patients (mean age 66+/-11.3 years) previously treated with me …
Severe sulfonylurea-induced hypoglycemia: a problem of uncritical prescription and deficiencies of diabetes care in geriatric patients.
Holstein A, Hammer C, Hahn M, Kulamadayil NS, Kovacs P. Holstein A, et al. Expert Opin Drug Saf. 2010 Sep;9(5):675-81. doi: 10.1517/14740338.2010.492777. Expert Opin Drug Saf. 2010. PMID: 20553106

Severe hypoglycemia was defined as a symptomatic event requiring treatment with intravenous glucose and was confirmed by a blood glucose measurement of < 50 mg/dl. ...Two-thirds of all subjects lived independently at home whereas a third were cared for by

Severe hypoglycemia was defined as a symptomatic event requiring treatment with intravenous glucose and was confirmed by a blo …
Oral antidiabetic drug metabolism: pharmacogenomics and drug interactions.
Holstein A, Beil W. Holstein A, et al. Expert Opin Drug Metab Toxicol. 2009 Mar;5(3):225-41. doi: 10.1517/17425250902806424. Expert Opin Drug Metab Toxicol. 2009. PMID: 19331589 Review.
METHODS: A PubMed literature search was performed to select the most recent and relevant publications examining OAD metabolism and the effects of concomitant use of OADs. ...As metformin is cardiovascular protective and is not metabolised through the hepatic cytochrome P45 …
METHODS: A PubMed literature search was performed to select the most recent and relevant publications examining OAD metabolism and th …
Clinical implications of hepatogenous diabetes in liver cirrhosis.
Holstein A, Hinze S, Thiessen E, Plaschke A, Egberts EH. Holstein A, et al. J Gastroenterol Hepatol. 2002 Jun;17(6):677-81. doi: 10.1046/j.1440-1746.2002.02755.x. J Gastroenterol Hepatol. 2002. PMID: 12100613
The examination included a history, determination of basal C-peptide and glycosylated hemoglobin (HbA(1c)) and, in some cases, a 3 h oral glucose tolerance test with 100 g glucose. ...Sixteen percent of patients with hepatogenous diabetes had a family history …
The examination included a history, determination of basal C-peptide and glycosylated hemoglobin (HbA(1c)) and, in some cases, a
The Glu23Lys polymorphism in KCNJ11 and impaired hypoglycaemia awareness in patients with type 1 diabetes.
Holstein A, Plaschke A, Stumvoll M, Kovacs P. Holstein A, et al. J Hum Genet. 2005;50(10):530-533. doi: 10.1007/s10038-005-0288-y. Epub 2005 Sep 2. J Hum Genet. 2005. PMID: 16142506
Genotyping of the Glu23Lys in a cohort of T1D subjects was done using the TaqMan allelic discrimination assay (frequency of the Lys-allele = 0.35; P = 0.57 for Hardy-Weinberg equilibrium). ...Even though the study provides a relatively large dataset, it is possible …
Genotyping of the Glu23Lys in a cohort of T1D subjects was done using the TaqMan allelic discrimination assay (frequency of the Lys-a …
Severe hypoglycemia due to possible interaction between glibenclamide and sorafenib in a patient with hepatocellular carcinoma.
Holstein A, Kovacs P, Beil W. Holstein A, et al. Curr Drug Saf. 2013 Apr;8(2):148-52. doi: 10.2174/15748863113089990027. Curr Drug Saf. 2013. PMID: 23845193
A 70-year old Caucasian male with liver cirrhosis Child-Pugh A, advanced hepatocellular carcinoma and diabetes had a stable glycemic control being treated with glibenclamide (3.5 mg twice daily). After the first daily dose of the TKI sorafenib (800 mg) the pa
A 70-year old Caucasian male with liver cirrhosis Child-Pugh A, advanced hepatocellular carcinoma and diabetes had a st
Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia.
Holstein A, Hahn M, Patzer O, Seeringer A, Kovacs P, Stingl J. Holstein A, et al. Eur J Clin Pharmacol. 2011 May;67(5):471-6. doi: 10.1007/s00228-010-0976-1. Epub 2011 Jan 7. Eur J Clin Pharmacol. 2011. PMID: 21213107
METHODS: In a prospective population-based case-control study, CYP2C9 allelic variants of 102 diabetic patients with SH were compared with a matched group of 101 SU-treated patients without a history of SH. ...SH was defined as a symptomatic event requ …
METHODS: In a prospective population-based case-control study, CYP2C9 allelic variants of 102 diabetic patients with SH were compared …
Substantial increase in incidence of severe hypoglycemia between 1997-2000 and 2007-2010: a German longitudinal population-based study.
Holstein A, Patzer OM, Machalke K, Holstein JD, Stumvoll M, Kovacs P. Holstein A, et al. Among authors: holstein jd. Diabetes Care. 2012 May;35(5):972-5. doi: 10.2337/dc11-1470. Epub 2012 Mar 12. Diabetes Care. 2012. PMID: 22410817 Free PMC article.
This was defined as a symptomatic event requiring treatment with intravenous glucose and being confirmed by a blood glucose measurement of <50 mg/dL. ...CONCLUSIONS: Within a 10-year period, there was an intensification of antihyperglycemic therapy in incr …
This was defined as a symptomatic event requiring treatment with intravenous glucose and being confirmed by a blood glucose me …
Self-reported Hypoglycaemic Events in 2 430 Patients with Insulin-treated Diabetes in the German Sub-population of the HAT Study.
Kern W, Holstein A, Moenninghoff C, Kienhöfer J, Riedl M, Kulzer B. Kern W, et al. Among authors: holstein a. Exp Clin Endocrinol Diabetes. 2017 Oct;125(9):592-597. doi: 10.1055/s-0043-112350. Epub 2017 Jul 27. Exp Clin Endocrinol Diabetes. 2017. PMID: 28750429 Free PMC article.
This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient diaries assessing patients aged ≥18 years in Germany, with type 1 diabetes (T1D) (n=811) or type 2 diabetes (T2D) (n=1 619) treated with insul …
This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient di …
Accumulation of severe hypoglycemia at weekends and in warm seasons in patients with type 1 diabetes but not with type 2 diabetes.
Holstein A, Wohland T, Patzer OM, Trachte F, Kovacs P, Holstein JD. Holstein A, et al. Among authors: holstein jd. J Diabetes Complications. 2016 Sep-Oct;30(7):1308-14. doi: 10.1016/j.jdiacomp.2016.05.026. Epub 2016 Jun 3. J Diabetes Complications. 2016. PMID: 27311787
AIMS: To determine the influence of daytime, weekdays and seasons on the frequency of severe hypoglycemia (SH) in a German population. ...SH was defined as a symptomatic event requiring treatment with intravenous glucose or administration of glucagon and being confi …
AIMS: To determine the influence of daytime, weekdays and seasons on the frequency of severe hypoglycemia (SH) in a German population …
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