Holt IJ - Search Results

1

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP. Reijns MA, et al. Among authors: holt ij. Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10. Cell. 2012. PMID: 22579044 Free PMC article.

2

Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model.

Moss CF, Dalla Rosa I, Hunt LE, Yasukawa T, Young R, Jones AWE, Reddy K, Desai R, Virtue S, Elgar G, Voshol P, Taylor MS, Holt IJ, Reijns MAM, Spinazzola A. Moss CF, et al. Among authors: holt ij. Nucleic Acids Res. 2017 Dec 15;45(22):12808-12815. doi: 10.1093/nar/gkx1009. Nucleic Acids Res. 2017. PMID: 29106596 Free PMC article.

3

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT, Holt IJ. Yang MY, et al. Among authors: holt ij. Cell. 2002 Nov 15;111(4):495-505. doi: 10.1016/s0092-8674(02)01075-9. Cell. 2002. PMID: 12437923 Free article.

4

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ. Pohjoismäki JL, et al. Among authors: holt ij. J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23. J Mol Biol. 2010. PMID: 20184890 Free PMC article.

5

Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA.

Holt IJ, Lorimer HE, Jacobs HT. Holt IJ, et al. Cell. 2000 Mar 3;100(5):515-24. doi: 10.1016/s0092-8674(00)80688-1. Cell. 2000. PMID: 10721989 Free article.

6

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

Yasukawa T, Yang MY, Jacobs HT, Holt IJ. Yasukawa T, et al. Among authors: holt ij. Mol Cell. 2005 Jun 10;18(6):651-62. doi: 10.1016/j.molcel.2005.05.002. Mol Cell. 2005. PMID: 15949440 Free article.

7

Minimizing the damage: repair pathways keep mitochondrial DNA intact.

Kazak L, Reyes A, Holt IJ. Kazak L, et al. Among authors: holt ij. Nat Rev Mol Cell Biol. 2012 Oct;13(10):659-71. doi: 10.1038/nrm3439. Epub 2012 Sep 20. Nat Rev Mol Cell Biol. 2012. PMID: 22992591 Review.

8

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.

Holmes JB, Akman G, Wood SR, Sakhuja K, Cerritelli SM, Moss C, Bowmaker MR, Jacobs HT, Crouch RJ, Holt IJ. Holmes JB, et al. Among authors: holt ij. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9334-9. doi: 10.1073/pnas.1503653112. Epub 2015 Jul 10. Proc Natl Acad Sci U S A. 2015. PMID: 26162680 Free PMC article.

9

The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.

He J, Mao CC, Reyes A, Sembongi H, Di Re M, Granycome C, Clippingdale AB, Fearnley IM, Harbour M, Robinson AJ, Reichelt S, Spelbrink JN, Walker JE, Holt IJ. He J, et al. Among authors: holt ij. J Cell Biol. 2007 Jan 15;176(2):141-6. doi: 10.1083/jcb.200609158. Epub 2007 Jan 8. J Cell Biol. 2007. PMID: 17210950 Free PMC article.

10

PrimPol, an archaic primase/polymerase operating in human cells.

García-Gómez S, Reyes A, Martínez-Jiménez MI, Chocrón ES, Mourón S, Terrados G, Powell C, Salido E, Méndez J, Holt IJ, Blanco L. García-Gómez S, et al. Among authors: holt ij. Mol Cell. 2013 Nov 21;52(4):541-53. doi: 10.1016/j.molcel.2013.09.025. Epub 2013 Oct 24. Mol Cell. 2013. PMID: 24207056 Free PMC article.

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