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Introduction of heteroplasmic mitochondrial DNA (mtDNA) from a patient with NARP into two human rho degrees cell lines is associated either with selection and maintenance of NARP mutant mtDNA or failure to maintain mtDNA.
Vergani L, Rossi R, Brierley CH, Hanna M, Holt IJ. Vergani L, et al. Hum Mol Genet. 1999 Sep;8(9):1751-5. doi: 10.1093/hmg/8.9.1751. Hum Mol Genet. 1999. PMID: 10441339
Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA.
Malena A, Pantic B, Borgia D, Sgarbi G, Solaini G, Holt IJ, Spinazzola A, Perissinotto E, Sandri M, Baracca A, Vergani L. Malena A, et al. Autophagy. 2016 Nov;12(11):2098-2112. doi: 10.1080/15548627.2016.1226734. Epub 2016 Sep 14. Autophagy. 2016. PMID: 27627835 Free PMC article.
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