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Klebsiella pneumoniae Population Genomics and Antimicrobial-Resistant Clones.
Wyres KL, Holt KE. Wyres KL, et al. Trends Microbiol. 2016 Dec;24(12):944-956. doi: 10.1016/j.tim.2016.09.007. Epub 2016 Oct 11. Trends Microbiol. 2016. PMID: 27742466 Review.
Typhoid in Kenya is associated with a dominant multidrug-resistant Salmonella enterica serovar Typhi haplotype that is also widespread in Southeast Asia.
Kariuki S, Revathi G, Kiiru J, Mengo DM, Mwituria J, Muyodi J, Munyalo A, Teo YY, Holt KE, Kingsley RA, Dougan G. Kariuki S, et al. J Clin Microbiol. 2010 Jun;48(6):2171-6. doi: 10.1128/JCM.01983-09. Epub 2010 Apr 14. J Clin Microbiol. 2010. PMID: 20392916 Free PMC article.
High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese children.
Holt KE, Baker S, Dongol S, Basnyat B, Adhikari N, Thorson S, Pulickal AS, Song Y, Parkhill J, Farrar JJ, Murdoch DR, Kelly DF, Pollard AJ, Dougan G. Holt KE, et al. BMC Infect Dis. 2010 May 31;10:144. doi: 10.1186/1471-2334-10-144. BMC Infect Dis. 2010. PMID: 20509974 Free PMC article.
Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.
Holt KE, Dolecek C, Chau TT, Duy PT, La TT, Hoang NV, Nga TV, Campbell JI, Manh BH, Vinh Chau NV, Hien TT, Farrar J, Dougan G, Baker S. Holt KE, et al. PLoS Negl Trop Dis. 2011 Jan 4;5(1):e929. doi: 10.1371/journal.pntd.0000929. PLoS Negl Trop Dis. 2011. PMID: 21245916 Free PMC article. Clinical Trial.
Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.
Holt KE, Phan MD, Baker S, Duy PT, Nga TV, Nair S, Turner AK, Walsh C, Fanning S, Farrell-Ward S, Dutta S, Kariuki S, Weill FX, Parkhill J, Dougan G, Wain J. Holt KE, et al. PLoS Negl Trop Dis. 2011 Jul;5(7):e1245. doi: 10.1371/journal.pntd.0001245. Epub 2011 Jul 19. PLoS Negl Trop Dis. 2011. PMID: 21811646 Free PMC article.
High-resolution genotyping of the endemic Salmonella Typhi population during a Vi (typhoid) vaccination trial in Kolkata.
Holt KE, Dutta S, Manna B, Bhattacharya SK, Bhaduri B, Pickard DJ, Ochiai RL, Ali M, Clemens JD, Dougan G. Holt KE, et al. PLoS Negl Trop Dis. 2012 Jan;6(1):e1490. doi: 10.1371/journal.pntd.0001490. Epub 2012 Jan 31. PLoS Negl Trop Dis. 2012. PMID: 22303491 Free PMC article.
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe.
Holt KE, Baker S, Weill FX, Holmes EC, Kitchen A, Yu J, Sangal V, Brown DJ, Coia JE, Kim DW, Choi SY, Kim SH, da Silveira WD, Pickard DJ, Farrar JJ, Parkhill J, Dougan G, Thomson NR. Holt KE, et al. Nat Genet. 2012 Sep;44(9):1056-9. doi: 10.1038/ng.2369. Epub 2012 Aug 5. Nat Genet. 2012. PMID: 22863732 Free PMC article.
Genomic insights to control the emergence of vancomycin-resistant enterococci.
Howden BP, Holt KE, Lam MM, Seemann T, Ballard S, Coombs GW, Tong SY, Grayson ML, Johnson PD, Stinear TP. Howden BP, et al. mBio. 2013 Aug 13;4(4):e00412-13. doi: 10.1128/mBio.00412-13. mBio. 2013. PMID: 23943759 Free PMC article.
Identification of a marker for two lineages within the GC1 clone of Acinetobacter baumannii.
Hamidian M, Wynn M, Holt KE, Pickard D, Dougan G, Hall RM. Hamidian M, et al. J Antimicrob Chemother. 2014 Feb;69(2):557-8. doi: 10.1093/jac/dkt379. Epub 2013 Sep 29. J Antimicrob Chemother. 2014. PMID: 24080502 Free PMC article. No abstract available.
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