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32 results
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The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Among authors: holtzclaw wd. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
Dinkova-Kostova AT, Holtzclaw WD, Wakabayashi N. Dinkova-Kostova AT, et al. Among authors: holtzclaw wd. Biochemistry. 2005 May 10;44(18):6889-99. doi: 10.1021/bi047434h. Biochemistry. 2005. PMID: 15865434
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Dinkova-Kostova AT, et al. Among authors: holtzclaw wd. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. doi: 10.1073/pnas.0500815102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767573 Free PMC article.
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Among authors: holtzclaw wd. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Dinkova-Kostova AT, et al. Among authors: holtzclaw wd. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. doi: 10.1073/pnas.172398899. Epub 2002 Aug 22. Proc Natl Acad Sci U S A. 2002. PMID: 12193649 Free PMC article.
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.
Talalay P, Dinkova-Kostova AT, Holtzclaw WD. Talalay P, et al. Among authors: holtzclaw wd. Adv Enzyme Regul. 2003;43:121-34. doi: 10.1016/s0065-2571(02)00038-9. Adv Enzyme Regul. 2003. PMID: 12791387 Review. No abstract available.
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.
Putzer RR, Zhang Y, Prestera T, Holtzclaw WD, Wade KL, Talalay P. Putzer RR, et al. Among authors: holtzclaw wd. Chem Res Toxicol. 1995 Jan-Feb;8(1):103-10. doi: 10.1021/tx00043a014. Chem Res Toxicol. 1995. PMID: 7703353
Chemoprotection against cancer by phase 2 enzyme induction.
Talalay P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y. Talalay P, et al. Among authors: holtzclaw wd. Toxicol Lett. 1995 Dec;82-83:173-9. doi: 10.1016/0378-4274(95)03553-2. Toxicol Lett. 1995. PMID: 8597048 Review.
Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.
Holtzclaw WD, Dinkova-Kostova AT, Talalay P. Holtzclaw WD, et al. Adv Enzyme Regul. 2004;44:335-67. doi: 10.1016/j.advenzreg.2003.11.013. Adv Enzyme Regul. 2004. PMID: 15581500 Review. No abstract available.
Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency.
Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK. Fahey JW, et al. Among authors: holtzclaw wd. Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600766. Epub 2017 Feb 8. Mol Nutr Food Res. 2017. PMID: 27935214
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