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Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
Hanks BA, Holtzhausen A, Evans KS, Jamieson R, Gimpel P, Campbell OM, Hector-Greene M, Sun L, Tewari A, George A, Starr M, Nixon AB, Augustine C, Beasley G, Tyler DS, Osada T, Morse MA, Ling L, Lyerly HK, Blobe GC. Hanks BA, et al. Among authors: holtzhausen a. J Clin Invest. 2013 Sep;123(9):3925-40. doi: 10.1172/JCI65745. Epub 2013 Aug 8. J Clin Invest. 2013. PMID: 23925295 Free PMC article.
Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking.
Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS, Pecot CV. Porrello A, et al. Among authors: holtzhausen a. Nat Commun. 2018 May 18;9(1):1988. doi: 10.1038/s41467-018-04355-w. Nat Commun. 2018. PMID: 29777108 Free PMC article.
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P. Jiang Y, et al. Among authors: holtzhausen a. Nat Commun. 2019 Apr 3;10(1):1515. doi: 10.1038/s41467-019-09233-7. Nat Commun. 2019. PMID: 30944303 Free PMC article.
Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy.
Theivanthiran B, Yarla N, Haykal T, Nguyen YV, Cao L, Ferreira M, Holtzhausen A, Al-Rohil R, Salama AKS, Beasley GM, Plebanek MP, DeVito NC, Hanks BA. Theivanthiran B, et al. Among authors: holtzhausen a. Sci Transl Med. 2022 Nov 23;14(672):eabq7019. doi: 10.1126/scitranslmed.abq7019. Epub 2022 Nov 23. Sci Transl Med. 2022. PMID: 36417489 Free PMC article.
17 results