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Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.
Lopez-Atalaya JP, Roussel BD, Levrat D, Parcq J, Nicole O, Hommet Y, Benchenane K, Castel H, Leprince J, To Van D, Bureau R, Rault S, Vaudry H, Petersen KU, Santos JS, Ali C, Vivien D. Lopez-Atalaya JP, et al. Among authors: hommet y. J Cereb Blood Flow Metab. 2008 Jun;28(6):1212-21. doi: 10.1038/jcbfm.2008.14. Epub 2008 Mar 12. J Cereb Blood Flow Metab. 2008. PMID: 18334994
PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAalpha1) prevents the passage of tissue-type plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity.
Roussel BD, Hommet Y, Macrez R, Schulz T, Petersen KU, Berezowski V, Cecchelli R, Ali C, Vivien D. Roussel BD, et al. Among authors: hommet y. Thromb Haemost. 2009 Sep;102(3):606-8. doi: 10.1160/TH09-02-0114. Thromb Haemost. 2009. PMID: 19718485 Free article. No abstract available.
Tissue plasminogen activator prevents white matter damage following stroke.
Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, Hernangómez M, Montagne A, Liot G, Guaza C, Maubert E, Ali C, Vivien D, Docagne F. Correa F, et al. Among authors: hommet y. J Exp Med. 2011 Jun 6;208(6):1229-42. doi: 10.1084/jem.20101880. Epub 2011 May 16. J Exp Med. 2011. PMID: 21576385 Free PMC article.
Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis.
Macrez R, Obiang P, Gauberti M, Roussel B, Baron A, Parcq J, Cassé F, Hommet Y, Orset C, Agin V, Bezin L, Berrocoso TG, Petersen KU, Montaner J, Maubert E, Vivien D, Ali C. Macrez R, et al. Among authors: hommet y. Stroke. 2011 Aug;42(8):2315-22. doi: 10.1161/STROKEAHA.110.606293. Epub 2011 Jun 16. Stroke. 2011. PMID: 21680906
Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.
Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E, Vivien D. Parcq J, et al. Among authors: hommet y. Cell Death Differ. 2012 Dec;19(12):1983-91. doi: 10.1038/cdd.2012.86. Epub 2012 Jun 29. Cell Death Differ. 2012. PMID: 22743997 Free PMC article.
30 results