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Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ. Leslie A, et al. Among authors: honeyborne i. J Immunol. 2006 Oct 1;177(7):4699-708. doi: 10.4049/jimmunol.177.7.4699. J Immunol. 2006. PMID: 16982909
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder P. Leslie A, et al. Among authors: honeyborne i. J Exp Med. 2005 Mar 21;201(6):891-902. doi: 10.1084/jem.20041455. J Exp Med. 2005. PMID: 15781581 Free PMC article.
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K, van der Stok M, McCarthy N, Rousseau CM, Addo M, Mullins JI, Brander C, Kiepiela P, Walker BD, Goulder PJ. Honeyborne I, et al. J Virol. 2007 Apr;81(7):3667-72. doi: 10.1128/JVI.02689-06. Epub 2007 Jan 24. J Virol. 2007. PMID: 17251285 Free PMC article.
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Crawford H, Prado JG, Leslie A, Hué S, Honeyborne I, Reddy S, van der Stok M, Mncube Z, Brander C, Rousseau C, Mullins JI, Kaslow R, Goepfert P, Allen S, Hunter E, Mulenga J, Kiepiela P, Walker BD, Goulder PJ. Crawford H, et al. Among authors: honeyborne i. J Virol. 2007 Aug;81(15):8346-51. doi: 10.1128/JVI.00465-07. Epub 2007 May 16. J Virol. 2007. PMID: 17507468 Free PMC article.
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJ. Kiepiela P, et al. Among authors: honeyborne i. Nature. 2004 Dec 9;432(7018):769-75. doi: 10.1038/nature03113. Nature. 2004. PMID: 15592417
Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
Day CL, Kiepiela P, Leslie AJ, van der Stok M, Nair K, Ismail N, Honeyborne I, Crawford H, Coovadia HM, Goulder PJ, Walker BD, Klenerman P. Day CL, et al. Among authors: honeyborne i. J Virol. 2007 Jan;81(1):434-8. doi: 10.1128/JVI.01754-06. Epub 2006 Oct 18. J Virol. 2007. PMID: 17050606 Free PMC article.
Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Matthews PC, Prendergast A, Leslie A, Crawford H, Payne R, Rousseau C, Rolland M, Honeyborne I, Carlson J, Kadie C, Brander C, Bishop K, Mlotshwa N, Mullins JI, Coovadia H, Ndung'u T, Walker BD, Heckerman D, Goulder PJ. Matthews PC, et al. Among authors: honeyborne i. J Virol. 2008 Sep;82(17):8548-59. doi: 10.1128/JVI.00580-08. Epub 2008 Jul 2. J Virol. 2008. PMID: 18596105 Free PMC article.
37 results