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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 4
1965 2
1966 3
1967 3
1968 5
1969 2
1970 3
1971 1
1973 2
1974 3
1975 1
1976 2
1977 3
1978 3
1979 3
1980 11
1981 8
1982 16
1983 9
1984 17
1985 18
1986 18
1987 23
1988 30
1989 22
1990 17
1991 20
1992 13
1993 17
1994 16
1995 12
1996 18
1997 23
1998 18
1999 23
2000 23
2001 29
2002 31
2003 28
2004 24
2005 28
2006 28
2007 31
2008 24
2009 28
2010 16
2011 21
2012 15
2013 16
2014 16
2015 13
2016 9
2017 13
2018 9
2019 5
2020 14
2021 16
2022 10
2023 17
2024 12
2025 17
2026 11

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858 results

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Page 1
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T. Freeman GJ, et al. Among authors: honjo t. J Exp Med. 2000 Oct 2;192(7):1027-34. doi: 10.1084/jem.192.7.1027. J Exp Med. 2000. PMID: 11015443 Free PMC article.
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, Nomura Y, Menzies R, Tajima M, Kitaoka K, Haku Y, Delghandi S, Yurimoto K, Matsuda F, Iwata S, Ogura T, Fagarasan S, Honjo T. Al-Habsi M, et al. Among authors: honjo t. Science. 2022 Oct 28;378(6618):eabj3510. doi: 10.1126/science.abj3510. Epub 2022 Oct 28. Science. 2022. PMID: 36302005
B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity.
Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S. Zhang B, et al. Among authors: honjo t. Nature. 2021 Nov;599(7885):471-476. doi: 10.1038/s41586-021-04082-1. Epub 2021 Nov 3. Nature. 2021. PMID: 34732892 Free PMC article.
Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment.
Haku Y, Kitaoka K, Ichimaru K, Hirano T, Wang J, Sonomura K, Maruo A, Hirose S, Wang Y, Ito K, Kozuki T, Yurimoto K, Kiyono M, Kosako H, Menju T, Date H, Kobayashi T, Omori K, Yaguchi T, Honjo T, Chamoto K. Haku Y, et al. Among authors: honjo t. Nat Immunol. 2026 Feb;27(2):281-294. doi: 10.1038/s41590-025-02370-w. Epub 2026 Jan 7. Nat Immunol. 2026. PMID: 41501155 Free article.
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
Ogishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA, Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, Al Ali F, Rahman M, Aytekin C, Benson B, Dufort MJ, Domingo-Vila C, Moriya K, Shlomchik M, Uzel G, Gray PE, Suan D, Preece K, Chua I, Okada S, Chikuma S, Kiyonari H, Tree TI, Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG. Ogishi M, et al. Among authors: honjo t. Immunity. 2024 Dec 10;57(12):2790-2807.e15. doi: 10.1016/j.immuni.2024.10.014. Epub 2024 Nov 26. Immunity. 2024. PMID: 39603236 Free PMC article.
858 results