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Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.
Walsh AH, Cheng A, Honkanen RE. Walsh AH, et al. Among authors: honkanen re. FEBS Lett. 1997 Oct 27;416(3):230-4. doi: 10.1016/s0014-5793(97)01210-6. FEBS Lett. 1997. PMID: 9373158
Protein phosphatases in pancreatic islets.
Ortsäter H, Grankvist N, Honkanen RE, Sjöholm Å. Ortsäter H, et al. Among authors: honkanen re. J Endocrinol. 2014 Jun;221(3):R121-44. doi: 10.1530/JOE-14-0002. Epub 2014 Mar 28. J Endocrinol. 2014. PMID: 24681827 Free PMC article. Review.
Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells.
Lehtihet M, Webb DL, Honkanen RE, Sjöholm A. Lehtihet M, et al. Among authors: honkanen re. Biochem Biophys Res Commun. 2005 Mar 11;328(2):601-7. doi: 10.1016/j.bbrc.2005.01.024. Biochem Biophys Res Commun. 2005. PMID: 15694391
Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells.
Sjöholm A, Lehtihet M, Efanov AM, Zaitsev SV, Berggren PO, Honkanen RE. Sjöholm A, et al. Among authors: honkanen re. Endocrinology. 2002 Dec;143(12):4592-8. doi: 10.1210/en.2002-220672. Endocrinology. 2002. PMID: 12446586
Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases.
Lehtihet M, Honkanen RE, Sjöholm A. Lehtihet M, et al. Among authors: honkanen re. Biochem Biophys Res Commun. 2004 Apr 9;316(3):893-7. doi: 10.1016/j.bbrc.2004.02.144. Biochem Biophys Res Commun. 2004. PMID: 15033485
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Lawhorn BG, et al. Among authors: honkanen re. J Am Chem Soc. 2006 Dec 27;128(51):16720-32. doi: 10.1021/ja066477d. J Am Chem Soc. 2006. PMID: 17177422 Free PMC article.
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. Swingle MR, et al. Among authors: honkanen re. J Pharmacol Exp Ther. 2009 Oct;331(1):45-53. doi: 10.1124/jpet.109.155630. Epub 2009 Jul 10. J Pharmacol Exp Ther. 2009. PMID: 19592665 Free PMC article.
Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.
Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL. Buck SB, et al. Among authors: honkanen re. J Am Chem Soc. 2003 Dec 24;125(51):15694-5. doi: 10.1021/ja038672n. J Am Chem Soc. 2003. PMID: 14677930
Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.
Swingle MR, Honkanen RE, Ciszak EM. Swingle MR, et al. Among authors: honkanen re. J Biol Chem. 2004 Aug 6;279(32):33992-9. doi: 10.1074/jbc.M402855200. Epub 2004 May 23. J Biol Chem. 2004. PMID: 15155720
Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).
Swingle MR, Honkanen RE. Swingle MR, et al. Among authors: honkanen re. Assay Drug Dev Technol. 2014 Oct;12(8):481-96. doi: 10.1089/adt.2014.603. Assay Drug Dev Technol. 2014. PMID: 25383722 Free PMC article.
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