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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1994 4
1996 1
1998 2
1999 3
2000 1
2001 1
2002 1
2003 5
2004 4
2005 6
2006 7
2007 12
2008 18
2009 24
2010 23
2011 26
2012 32
2013 34
2014 30
2015 35
2016 41
2017 52
2018 59
2019 46
2020 58
2021 44
2022 27
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541 results
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Page 1
Safety and Toxicology of Magnolol and Honokiol.
Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Sarrica A, et al. Planta Med. 2018 Nov;84(16):1151-1164. doi: 10.1055/a-0642-1966. Epub 2018 Jun 20. Planta Med. 2018. PMID: 29925102 Free article. Review.
Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antis …
Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines …
Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition.
Avila-Carrasco L, Majano P, Sánchez-Toméro JA, Selgas R, López-Cabrera M, Aguilera A, González Mateo G. Avila-Carrasco L, et al. Front Pharmacol. 2019 Jul 30;10:715. doi: 10.3389/fphar.2019.00715. eCollection 2019. Front Pharmacol. 2019. PMID: 31417401 Free PMC article. Review.
Salvianolic acid-A and plumbagin block oxidative stress, while honokiol, gallic acid, piperlongumine, brusatol and paeoniflorin inhibit EMT transcription factors such as SNAIL, TWIST and ZEB. ...Additionally, this review highlights some relevant examples of clinical trials …
Salvianolic acid-A and plumbagin block oxidative stress, while honokiol, gallic acid, piperlongumine, brusatol and paeoniflorin inhib …
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model.
Zhang B, Wang PP, Hu KL, Li LN, Yu X, Lu Y, Chang HS. Zhang B, et al. Molecules. 2019 May 28;24(11):2035. doi: 10.3390/molecules24112035. Molecules. 2019. PMID: 31141940 Free PMC article.
Moreover, honokiol ameliorated LPS-induced NF-kappaB activation in the hippocampus and significantly reduced the levels of the pro-inflammatory cytokines; tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interferon gamma (IFN-gamma). ...In …
Moreover, honokiol ameliorated LPS-induced NF-kappaB activation in the hippocampus and significantly reduced the levels of the pro- …
Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity.
Guo C, Liu P, Deng G, Han Y, Chen Y, Cai C, Shen H, Deng G, Zeng S. Guo C, et al. Am J Cancer Res. 2021 Jun 15;11(6):3039-3054. eCollection 2021. Am J Cancer Res. 2021. PMID: 34249443 Free PMC article.
Colon cancer (CC) is a prevalent malignancy worldwide. Approaches to specifically induce tumor cell death have historically been a popular research topic. Honokiol (HNK), which exhibits highly efficient and specific anticancer effects, is a biphenolic compound found …
Colon cancer (CC) is a prevalent malignancy worldwide. Approaches to specifically induce tumor cell death have historically been a po …
Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery.
Zheng Z, Zhang J, Jiang J, He Y, Zhang W, Mo X, Kang X, Xu Q, Wang B, Huang Y. Zheng Z, et al. J Immunother Cancer. 2020 Aug;8(2):e000207. doi: 10.1136/jitc-2019-000207. J Immunother Cancer. 2020. PMID: 32817393 Free PMC article.
METHODS: In this study, an alpha7 nicotinic acetylcholine receptors (nAChRs)-binding peptide (D)CDX was used to modify the codelivery liposomes to achieve a 'three-birds-one-stone' delivery strategy, that is, multi-targeting the glioma vessel endothelium, glioma cells, and tumor- …
METHODS: In this study, an alpha7 nicotinic acetylcholine receptors (nAChRs)-binding peptide (D)CDX was used to modify the codelivery liposo …
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, Gupta MP. Pillai VB, et al. Nat Commun. 2015 Apr 14;6:6656. doi: 10.1038/ncomms7656. Nat Commun. 2015. PMID: 25871545 Free PMC article.
Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. ...
Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative …
Synthesis of Either C2- or C4'-Alkylated Derivatives of Honokiol and Their Biological Evaluation for Anti-inflammatory Activity.
Lee SH, Fei X, Lee C, Do HTT, Rhee I, Seo SY. Lee SH, et al. Chem Pharm Bull (Tokyo). 2019 Sep 1;67(9):966-976. doi: 10.1248/cpb.c19-00207. Epub 2019 Jun 28. Chem Pharm Bull (Tokyo). 2019. PMID: 31257308 Free article.
Honokiol, a biphenolic neolignan isolated from Magnolia officinalis, was reported to have a promising anti-inflammatory activity for the treatment of various diseases. There are many efforts on the synthesis and structure-activity relationship of honokiol der …
Honokiol, a biphenolic neolignan isolated from Magnolia officinalis, was reported to have a promising anti-inflammatory activi …
Honokiol: An anticancer lignan.
Rauf A, Patel S, Imran M, Maalik A, Arshad MU, Saeed F, Mabkhot YN, Al-Showiman SS, Ahmad N, Elsharkawy E. Rauf A, et al. Biomed Pharmacother. 2018 Nov;107:555-562. doi: 10.1016/j.biopha.2018.08.054. Epub 2018 Aug 13. Biomed Pharmacother. 2018. PMID: 30114639 Review.
Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studies. ...This review will shed light on the scopes and hurdles in the relevance of the bioactive lignan honokiol in cancer manage …
Honokiol has inhibitory role on the proliferation, invasion and survival of cancer cells in in vitro as well as in vivo studie …
Honokiol possesses potential anti-inflammatory effects on rheumatoid arthritis and GM-CSF can be a target for its treatment.
Wang XD, Wang YL, Gao WF. Wang XD, et al. Int J Clin Exp Pathol. 2015 Jul 1;8(7):7929-36. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26339358 Free PMC article.
OBJECTIVE: To observe the anti-inflammatory effects of honokiol in primary cultures of peripheral blood mononuclear cells of rheumatoid arthritis patients, the pro-inflammatory cytokines and potential targets were investigated. ...CONCLUSIONS: This stu …
OBJECTIVE: To observe the anti-inflammatory effects of honokiol in primary cultures of peripheral blood mononuclear cells of r …
Honokiol: A review of its pharmacological potential and therapeutic insights.
Rauf A, Olatunde A, Imran M, Alhumaydhi FA, Aljohani ASM, Khan SA, Uddin MS, Mitra S, Emran TB, Khayrullin M, Rebezov M, Kamal MA, Shariati MA. Rauf A, et al. Phytomedicine. 2021 Sep;90:153647. doi: 10.1016/j.phymed.2021.153647. Epub 2021 Jul 16. Phytomedicine. 2021. PMID: 34362632 Review.
PURPOSE: The objective of this review is to summarize the pharmacological potential and therapeutic insights of honokiol. STUDY DESIGN: Honokiol has been specified as a novel alternative to treat various disorders such as liver cancer, neuroprotective, anti-s …
PURPOSE: The objective of this review is to summarize the pharmacological potential and therapeutic insights of honokiol. STUDY DESIG …
541 results