Hop CE - Search Results

1

Species and gender differences in the formation of an active metabolite of a substituted 2,4-thiazolidinedione insulin sensitizer.

Beconi M, Mao A, Creighton M, Hop CE, Chiu SH, Eydelloth R, Franklin R, Tang F, Yu N, Vincent S. Beconi M, et al. Among authors: hop ce. Xenobiotica. 2003 Jul;33(7):767-87. doi: 10.1080/0049825031000108333. Xenobiotica. 2003. PMID: 12893525

2

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: hop ce. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

3

Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification.

Liu DQ, Hop CE, Beconi MG, Mao A, Chiu SH. Liu DQ, et al. Among authors: hop ce. Rapid Commun Mass Spectrom. 2001;15(19):1832-9. doi: 10.1002/rcm.442. Rapid Commun Mass Spectrom. 2001. PMID: 11565101

4

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.

Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE. Liu DQ, et al. Among authors: hop ce. Drug Metab Dispos. 2004 Sep;32(9):1023-31. doi: 10.1124/dmd.104.000059. Drug Metab Dispos. 2004. PMID: 15319345

5

Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on-line simultaneous quantification of a drug candidate and its six metabolites in dog plasma.

Xia YQ, Hop CE, Liu DQ, Vincent SH, Chiu SH. Xia YQ, et al. Among authors: hop ce. Rapid Commun Mass Spectrom. 2001;15(22):2135-44. doi: 10.1002/rcm.492. Rapid Commun Mass Spectrom. 2001. PMID: 11746878

6

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases.

Karanam BV, Hop CE, Liu DQ, Wallace M, Dean D, Satoh H, Komuro M, Awano K, Vincent SH. Karanam BV, et al. Among authors: hop ce. Drug Metab Dispos. 2004 Sep;32(9):1015-22. doi: 10.1124/dmd.104.000034. Drug Metab Dispos. 2004. PMID: 15319344

7

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes.

Agrawal AK, Hop CE, Pang J, Silva Elipe MV, Desai RC, Leung KH, Franklin RB. Agrawal AK, et al. Among authors: hop ce. J Pharm Biomed Anal. 2005 Feb 23;37(2):351-8. doi: 10.1016/j.jpba.2004.10.036. J Pharm Biomed Anal. 2005. PMID: 15708677

8

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: hop ce. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

9

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

Hop CE, Wang Y, Kumar S, Elipe MV, Raab CE, Dean DC, Poon GK, Keohane CA, Strauss J, Chiu SH, Curtis N, Elliott J, Gerhard U, Locker K, Morrison D, Mortishire-Smith R, Thomas S, Watt AP, Evans DC. Hop CE, et al. Drug Metab Dispos. 2002 Aug;30(8):937-43. doi: 10.1124/dmd.30.8.937. Drug Metab Dispos. 2002. PMID: 12124313

10

Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.

Takahashi RH, Ma S, Yue Q, Kim-Kang H, Yi Y, Ly J, Boggs JW, Fettes A, McClory A, Deng Y, Hop CE, Khojasteh SC, Choo EF. Takahashi RH, et al. Among authors: hop ce. Xenobiotica. 2017 Jan;47(1):50-65. doi: 10.3109/00498254.2016.1157645. Epub 2016 Apr 8. Xenobiotica. 2017. PMID: 27055783

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