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125 results
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In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods.
Poulin P, Kenny JR, Hop CE, Haddad S. Poulin P, et al. Among authors: hop ce. J Pharm Sci. 2012 Feb;101(2):838-51. doi: 10.1002/jps.22792. Epub 2011 Oct 18. J Pharm Sci. 2012. PMID: 22009717
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Mao J, Fan P, Wong S, Wang J, Ismaili MHA, Dean B, Hop CECA, Wright M, Chen Y. Mao J, et al. Pharm Res. 2017 Nov;34(11):2403-2414. doi: 10.1007/s11095-017-2246-8. Epub 2017 Aug 16. Pharm Res. 2017. PMID: 28815392
Prediction of drug distribution in subcutaneous xenografts of human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model to antineoplastic drugs.
Poulin P, Chen YH, Ding X, Gould SE, Hop CE, Messick K, Oeh J, Liederer BM. Poulin P, et al. Among authors: hop ce. J Pharm Sci. 2015 Apr;104(4):1508-21. doi: 10.1002/jps.24336. Epub 2015 Jan 14. J Pharm Sci. 2015. PMID: 25615572
Correlation of tissue-plasma partition coefficients between normal tissues and subcutaneous xenografts of human tumor cell lines in mouse as a prediction tool of drug penetration in tumors.
Poulin P, Hop CE, Salphati L, Liederer BM. Poulin P, et al. Among authors: hop ce. J Pharm Sci. 2013 Apr;102(4):1355-69. doi: 10.1002/jps.23452. Epub 2013 Jan 18. J Pharm Sci. 2013. PMID: 23334959
Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs.
Poulin P, Hop CE, Ho Q, Halladay JS, Haddad S, Kenny JR. Poulin P, et al. Among authors: hop ce. J Pharm Sci. 2012 Nov;101(11):4308-26. doi: 10.1002/jps.23288. Epub 2012 Aug 13. J Pharm Sci. 2012. PMID: 22890957
Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.
Mao J, Tay S, Khojasteh CS, Chen Y, Hop CE, Kenny JR. Mao J, et al. Among authors: hop ce. Pharm Res. 2016 May;33(5):1204-19. doi: 10.1007/s11095-016-1865-9. Epub 2016 Feb 11. Pharm Res. 2016. PMID: 26869174
Influence of the compound selection process on the performance of human clearance prediction methods.
Wong H, Lewin-Koh SC, Theil FP, Hop CE. Wong H, et al. Among authors: hop ce. J Pharm Sci. 2012 Feb;101(2):509-15. doi: 10.1002/jps.22786. Epub 2011 Oct 4. J Pharm Sci. 2012. PMID: 21976152
On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay.
Berezhkovskiy LM, Khojasteh SC, Halladay JS, Hop CE. Berezhkovskiy LM, et al. Among authors: hop ce. J Pharm Sci. 2009 Jun;98(6):1922-7. doi: 10.1002/jps.21582. J Pharm Sci. 2009. PMID: 18837013
Improving Confidence in the Determination of Free Fraction for Highly Bound Drugs Using Bidirectional Equilibrium Dialysis.
Chen YC, Kenny JR, Wright M, Hop CECA, Yan Z. Chen YC, et al. J Pharm Sci. 2019 Mar;108(3):1296-1302. doi: 10.1016/j.xphs.2018.10.011. Epub 2018 Oct 14. J Pharm Sci. 2019. PMID: 30326208
Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening.
Hop CE, Wang Z, Chen Q, Kwei G. Hop CE, et al. J Pharm Sci. 1998 Jul;87(7):901-3. doi: 10.1021/js970486q. J Pharm Sci. 1998. PMID: 9649361 No abstract available.
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