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Tumor Mutational Burden and Response Rate to PD-1 Inhibition.
Yarchoan M, Hopkins A, Jaffee EM. Yarchoan M, et al. Among authors: hopkins a. N Engl J Med. 2017 Dec 21;377(25):2500-2501. doi: 10.1056/NEJMc1713444. N Engl J Med. 2017. PMID: 29262275 Free PMC article. No abstract available.
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers.
Yarchoan M, Albacker LA, Hopkins AC, Montesion M, Murugesan K, Vithayathil TT, Zaidi N, Azad NS, Laheru DA, Frampton GM, Jaffee EM. Yarchoan M, et al. Among authors: hopkins ac. JCI Insight. 2019 Mar 21;4(6):e126908. doi: 10.1172/jci.insight.126908. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30895946 Free PMC article.
RESULTS: PD-L1 expression and TMB are not significantly correlated within most cancer subtypes, and they show only a marginal association at the tumor sample level (Pearson's correlation 0.084). ...FUNDING: Funding was provided by Foundation Medicine Inc., the Johns Hop …
RESULTS: PD-L1 expression and TMB are not significantly correlated within most cancer subtypes, and they show only a marginal associa …
Association between pretreatment lymphocyte count and response to PD1 inhibitors in head and neck squamous cell carcinomas.
Ho WJ, Yarchoan M, Hopkins A, Mehra R, Grossman S, Kang H. Ho WJ, et al. Among authors: hopkins a. J Immunother Cancer. 2018 Aug 31;6(1):84. doi: 10.1186/s40425-018-0395-x. J Immunother Cancer. 2018. PMID: 30170629 Free PMC article.
BACKGROUND: Low absolute lymphocyte count (ALC) has previously been established as a marker of poor prognosis in multiple cancer types. There is growing evidence that ALC may also be associated with response to immunotherapy. ...METHODS: Thirty-four R/M HNSCC patients who …
BACKGROUND: Low absolute lymphocyte count (ALC) has previously been established as a marker of poor prognosis in multiple cancer type …
Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data.
Davis-Marcisak EF, Sherman TD, Orugunta P, Stein-O'Brien GL, Puram SV, Roussos Torres ET, Hopkins AC, Jaffee EM, Favorov AV, Afsari B, Goff LA, Fertig EJ. Davis-Marcisak EF, et al. Among authors: hopkins ac. Cancer Res. 2019 Oct 1;79(19):5102-5112. doi: 10.1158/0008-5472.CAN-18-3882. Epub 2019 Jul 23. Cancer Res. 2019. PMID: 31337651 Free PMC article.
Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs.
Christmas BJ, Rafie CI, Hopkins AC, Scott BA, Ma HS, Cruz KA, Woolman S, Armstrong TD, Connolly RM, Azad NA, Jaffee EM, Roussos Torres ET. Christmas BJ, et al. Among authors: hopkins ac. Cancer Immunol Res. 2018 Dec;6(12):1561-1577. doi: 10.1158/2326-6066.CIR-18-0070. Epub 2018 Oct 19. Cancer Immunol Res. 2018. PMID: 30341213 Free PMC article.
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