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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2003 1
2004 6
2005 5
2006 4
2007 4
2008 2
2009 2
2010 2
2011 4
2012 12
2013 11
2014 7
2015 3
2016 4
2017 4
2019 2
2020 2
2021 4
2022 0
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Page 1
Acute skeletal muscle wasting in critical illness.
Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Phadke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE. Puthucheary ZA, et al. Among authors: hopkinson ns. JAMA. 2013 Oct 16;310(15):1591-600. doi: 10.1001/jama.2013.278481. JAMA. 2013. PMID: 24108501
IMPORTANCE: Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. OBJECTIVE: To perform a comprehensive prospective characterization of skeletal muscle wasting, defining the pathogenic roles of altered protein synth …
IMPORTANCE: Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. OBJECTIVE: To pe …
Reduced skeletal muscle endurance and ventilatory efficiency during exercise in adult smokers without airflow obstruction.
Sadaka AS, Faisal A, Khalil YM, Mourad SM, Zidan MH, Polkey MI, Hopkinson NS. Sadaka AS, et al. Among authors: hopkinson ns. J Appl Physiol (1985). 2021 Apr 1;130(4):976-986. doi: 10.1152/japplphysiol.00762.2020. Epub 2021 Jan 14. J Appl Physiol (1985). 2021. PMID: 33444125 Free article.
Adult smokers without airflow obstruction have reduced skeletal muscle endurance and ventilatory efficiency compared with never-smoker controls, despite similar daily physical activity levels, which contributed to reduced peak exercise capacity.NEW & NOTEWORTHY In adul …
Adult smokers without airflow obstruction have reduced skeletal muscle endurance and ventilatory efficiency compared with never-smoke …
Vitamin D and skeletal muscle strength and endurance in COPD.
Jackson AS, Shrikrishna D, Kelly JL, Kemp SV, Hart N, Moxham J, Polkey MI, Kemp P, Hopkinson NS. Jackson AS, et al. Among authors: hopkinson ns. Eur Respir J. 2013 Feb;41(2):309-16. doi: 10.1183/09031936.00043112. Epub 2012 May 3. Eur Respir J. 2013. PMID: 22556020 Free article.
It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in chronic obstructive pulmonary disease (COPD). ...In contrast with healthy controls, muscle strength is not associated with vitamin D levels in COPD, which may represent …
It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in chronic obstructive pulmonary disea …
Klotho and smoking--An interplay influencing the skeletal muscle function deficits that occur in COPD.
Patel MS, Donaldson AV, Lewis A, Natanek SA, Lee JY, Andersson YM, Haji G, Jackson SG, Bolognese BJ, Foley JP, Podolin PL, Bruijnzeel PL, Hart N, Hopkinson NS, Man WD, Kemp PR, Polkey MI. Patel MS, et al. Among authors: hopkinson ns. Respir Med. 2016 Apr;113:50-6. doi: 10.1016/j.rmed.2016.02.004. Epub 2016 Feb 15. Respir Med. 2016. PMID: 27021580 Free article.
BACKGROUND: Klotho is an 'anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including emphysema and muscle wasting. The objective of this study was to evaluate skeletal muscle and circulating Klotho p …
BACKGROUND: Klotho is an 'anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smoker …
MuRF-1 and atrogin-1 protein expression and quadriceps fiber size and muscle mass in stable patients with COPD.
Natanek SA, Riddoch-Contreras J, Marsh GS, Hopkinson NS, Moxham J, Man WD, Kemp PR, Polkey MI. Natanek SA, et al. Among authors: hopkinson ns. COPD. 2013 Oct;10(5):618-24. doi: 10.3109/15412555.2013.781577. Epub 2013 Jul 11. COPD. 2013. PMID: 23844868 Free PMC article.
INTRODUCTION: Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation during acute muscle atrophy. ...CONCLUSIONS: Chronic upregulation of ubiquitin ligases was …
INTRODUCTION: Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle RING-Finger Protein 1 (MuRF-1) and atrogi …
Yin Yang 1 expression and localisation in quadriceps muscle in COPD.
Natanek SA, Riddoch-Contreras J, Marsh GS, Hopkinson NS, Man WD, Moxham J, Polkey MI, Kemp PR. Natanek SA, et al. Among authors: hopkinson ns. Arch Bronconeumol. 2011 Jun;47(6):296-302. doi: 10.1016/j.arbres.2011.02.015. Epub 2011 May 11. Arch Bronconeumol. 2011. PMID: 21565439 English, Spanish.
INTRODUCTION: Yin Yang 1 (YY1) is a transcriptional repressor that inhibits muscle gene expression and myogenesis. YY1 has not previously been investigated in the skeletal muscle of patients with COPD. ...CONCLUSION: YY1 expression is associated with smaller quadric …
INTRODUCTION: Yin Yang 1 (YY1) is a transcriptional repressor that inhibits muscle gene expression and myogenesis. YY1 has not previo …
Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD.
Maddocks M, Shrikrishna D, Vitoriano S, Natanek SA, Tanner RJ, Hart N, Kemp PR, Moxham J, Polkey MI, Hopkinson NS. Maddocks M, et al. Among authors: hopkinson ns. Eur Respir J. 2014 Nov;44(5):1188-98. doi: 10.1183/09031936.00066414. Epub 2014 Jul 3. Eur Respir J. 2014. PMID: 24993908 Free PMC article.
Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of …
Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined …
Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo.
Patel MS, Lee J, Baz M, Wells CE, Bloch S, Lewis A, Donaldson AV, Garfield BE, Hopkinson NS, Natanek A, Man WD, Wells DJ, Baker EH, Polkey MI, Kemp PR. Patel MS, et al. Among authors: hopkinson ns. J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):436-48. doi: 10.1002/jcsm.12096. Epub 2015 Dec 29. J Cachexia Sarcopenia Muscle. 2016. PMID: 27239406 Free PMC article.
METHODS: We determined the expression of GDF-15 in the serum and muscle of patients with COPD and analysed the association of GDF-15 expression with muscle mass and exercise performance. ...Local over-expression of GDF-15 in mice caused wasting of the tibialis anter …
METHODS: We determined the expression of GDF-15 in the serum and muscle of patients with COPD and analysed the association of GDF-15 …
Patient symptoms and experience following COVID-19: results from a UK-wide survey.
Buttery S, Philip KEJ, Williams P, Fallas A, West B, Cumella A, Cheung C, Walker S, Quint JK, Polkey MI, Hopkinson NS. Buttery S, et al. Among authors: hopkinson ns. BMJ Open Respir Res. 2021 Nov;8(1):e001075. doi: 10.1136/bmjresp-2021-001075. BMJ Open Respir Res. 2021. PMID: 34732518 Free PMC article.
DESIGN: We conducted a mixed-methods analysis of responses to a survey accessed through a UK online post-COVID-19 support and information hub, between April and December 2020, about people's experiences after having acute COVID-19. PARTICIPANTS: 3290 respondents, 78% femal …
DESIGN: We conducted a mixed-methods analysis of responses to a survey accessed through a UK online post-COVID-19 support and information hu …
Abdominal muscle and quadriceps strength in chronic obstructive pulmonary disease.
Man WD, Hopkinson NS, Harraf F, Nikoletou D, Polkey MI, Moxham J. Man WD, et al. Among authors: hopkinson ns. Thorax. 2005 Sep;60(9):718-22. doi: 10.1136/thx.2005.040709. Epub 2005 May 27. Thorax. 2005. PMID: 15923239 Free PMC article.
BACKGROUND: Quadriceps muscle weakness is common in chronic obstructive pulmonary disease (COPD) but is not observed in a small hand muscle (adductor pollicis). ...By inference, we conclude that disuse and consequent deconditioning are important factors in the devel …
BACKGROUND: Quadriceps muscle weakness is common in chronic obstructive pulmonary disease (COPD) but is not observed in a small hand …
66 results