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A catalytic domain variant of mitofusin requiring a wildtype paralog for function uncouples mitochondrial outer-membrane tethering and fusion.
Engelhart EA, Hoppins S. Engelhart EA, et al. Among authors: hoppins s. J Biol Chem. 2019 May 17;294(20):8001-8014. doi: 10.1074/jbc.RA118.006347. Epub 2019 Apr 1. J Biol Chem. 2019. PMID: 30936207 Free PMC article.
The regulation of mitochondrial dynamics.
Hoppins S. Hoppins S. Curr Opin Cell Biol. 2014 Aug;29:46-52. doi: 10.1016/ Epub 2014 Apr 17. Curr Opin Cell Biol. 2014. PMID: 24747170 Review.
Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes.
Whitley BN, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Brady L, Tarnopolsky MA, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S. Whitley BN, et al. Among authors: hoppins s. Hum Mol Genet. 2018 Nov 1;27(21):3710-3719. doi: 10.1093/hmg/ddy287. Hum Mol Genet. 2018. PMID: 30085106 Free PMC article.
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.
Sloat SR, Whitley BN, Engelhart EA, Hoppins S. Sloat SR, et al. Among authors: hoppins s. Mol Biol Cell. 2019 Aug 1;30(17):2309-2319. doi: 10.1091/mbc.E19-05-0291. Epub 2019 Jun 12. Mol Biol Cell. 2019. PMID: 31188717 Free PMC article.
Mitochondrial dynamics and their potential as a therapeutic target.
Whitley BN, Engelhart EA, Hoppins S. Whitley BN, et al. Among authors: hoppins s. Mitochondrion. 2019 Nov;49:269-283. doi: 10.1016/j.mito.2019.06.002. Epub 2019 Jun 19. Mitochondrion. 2019. PMID: 31228566 Review.
Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax.
Samanas NB, Engelhart EA, Hoppins S. Samanas NB, et al. Among authors: hoppins s. Life Sci Alliance. 2020 Apr 3;3(5):e201900527. doi: 10.26508/lsa.201900527. Print 2020 May. Life Sci Alliance. 2020. PMID: 32245838 Free PMC article.
Cell-Free Analysis of Mitochondrial Fusion by Fluorescence Microscopy.
Samanas NB, Hoppins S. Samanas NB, et al. Among authors: hoppins s. Methods Mol Biol. 2020;2159:129-140. doi: 10.1007/978-1-0716-0676-6_10. Methods Mol Biol. 2020. PMID: 32529368
Alternative splicing gives rise to different isoforms of the Neurospora crassa Tob55 protein that vary in their ability to insert beta-barrel proteins into the outer mitochondrial membrane.
Hoppins SC, Go NE, Klein A, Schmitt S, Neupert W, Rapaport D, Nargang FE. Hoppins SC, et al. Genetics. 2007 Sep;177(1):137-49. doi: 10.1534/genetics.107.075051. Epub 2007 Jul 29. Genetics. 2007. PMID: 17660559 Free PMC article.
The molecular mechanism of mitochondrial fusion.
Hoppins S, Nunnari J. Hoppins S, et al. Biochim Biophys Acta. 2009 Jan;1793(1):20-6. doi: 10.1016/j.bbamcr.2008.07.005. Epub 2008 Jul 21. Biochim Biophys Acta. 2009. PMID: 18691613 Review.
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