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Production of 'hybrid' antibiotics by genetic engineering.
Hopwood DA, Malpartida F, Kieser HM, Ikeda H, Duncan J, Fujii I, Rudd BA, Floss HG, Omura S. Hopwood DA, et al. Nature. 1985 Apr 18-24;314(6012):642-4. doi: 10.1038/314642a0. Nature. 1985. PMID: 3857464
Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.
Ichinose K, Taguchi T, Bedford DJ, Ebizuka Y, Hopwood DA. Ichinose K, et al. J Bacteriol. 2001 May;183(10):3247-50. doi: 10.1128/JB.183.10.3247-3250.2001. J Bacteriol. 2001. PMID: 11325954 Free PMC article.
Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.
Kendrew SG, Hopwood DA, Marsh EN. Kendrew SG, et al. J Bacteriol. 1997 Jul;179(13):4305-10. doi: 10.1128/jb.179.13.4305-4310.1997. J Bacteriol. 1997. PMID: 9209048 Free PMC article.
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