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Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR.
Horigan G, McNulty H, Ward M, Strain JJ, Purvis J, Scott JM. Horigan G, et al. J Hypertens. 2010 Mar;28(3):478-86. doi: 10.1097/HJH.0b013e328334c126. J Hypertens. 2010. PMID: 19952781
Cholecalciferol supplementation throughout winter does not affect markers of bone turnover in healthy young and elderly adults.
Seamans KM, Hill TR, Wallace JM, Horigan G, Lucey AJ, Barnes MS, Taylor N, Bonham MP, Muldowney S, Duffy EM, Strain JJ, Kiely M, Cashman KD. Seamans KM, et al. Among authors: horigan g. J Nutr. 2010 Mar;140(3):454-60. doi: 10.3945/jn.109.113480. Epub 2010 Jan 20. J Nutr. 2010. PMID: 20089776 Clinical Trial.
Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults.
Barnes MS, Horigan G, Cashman KD, Hill TR, Forsythe LK, Lucey AJ, McSorley EM, Kiely M, Bonham MP, Magee PJ, Strain JJ, Wallace JM. Barnes MS, et al. Among authors: horigan g. J Nutr. 2011 Mar;141(3):476-81. doi: 10.3945/jn.110.131516. Epub 2011 Jan 26. J Nutr. 2011. PMID: 21270359 Clinical Trial.
B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension.
Ward M, Wilson CP, Strain JJ, Horigan G, Scott JM, McNulty H. Ward M, et al. Among authors: horigan g. Int J Vitam Nutr Res. 2011 Jul;81(4):240-4. doi: 10.1024/0300-9831/a000069. Int J Vitam Nutr Res. 2011. PMID: 22237773
Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up.
Wilson CP, Ward M, McNulty H, Strain JJ, Trouton TG, Horigan G, Purvis J, Scott JM. Wilson CP, et al. Among authors: horigan g. Am J Clin Nutr. 2012 Mar;95(3):766-72. doi: 10.3945/ajcn.111.026245. Epub 2012 Jan 25. Am J Clin Nutr. 2012. PMID: 22277556 Clinical Trial.
Incremental cholecalciferol supplementation up to 15 μg/d throughout winter at 51-55° N has no effect on biomarkers of cardiovascular risk in healthy young and older adults.
Muldowney S, Lucey AJ, Hill TR, Seamans KM, Taylor N, Wallace JM, Horigan G, Barnes MS, Bonham MP, Duffy EM, Strain JJ, Cashman KD, Kiely M. Muldowney S, et al. Among authors: horigan g. J Nutr. 2012 Aug;142(8):1519-25. doi: 10.3945/jn.111.154005. Epub 2012 Jun 27. J Nutr. 2012. PMID: 22739371 Clinical Trial.
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial.
Wilson CP, McNulty H, Ward M, Strain JJ, Trouton TG, Hoeft BA, Weber P, Roos FF, Horigan G, McAnena L, Scott JM. Wilson CP, et al. Among authors: horigan g. Hypertension. 2013 Jun;61(6):1302-8. doi: 10.1161/HYPERTENSIONAHA.111.01047. Epub 2013 Apr 22. Hypertension. 2013. PMID: 23608654 Clinical Trial.
Serum levels of miR-199a-5p correlates with blood pressure in premature cardiovascular disease patients homozygous for the MTHFR 677C > T polymorphism.
Lynch SM, Ward M, McNulty H, Angel CZ, Horigan G, Strain JJ, Purvis J, Tackett M, McKenna DJ. Lynch SM, et al. Among authors: horigan g. Genomics. 2020 Jan;112(1):669-676. doi: 10.1016/j.ygeno.2019.04.019. Epub 2019 Apr 25. Genomics. 2020. PMID: 31029863 Clinical Trial.
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.
Rooney M, Bottiglieri T, Wasek-Patterson B, McMahon A, Hughes CF, McCann A, Horigan G, Strain JJ, McNulty H, Ward M. Rooney M, et al. Among authors: horigan g. Biochimie. 2020 Jun;173:91-99. doi: 10.1016/j.biochi.2020.04.004. Epub 2020 Apr 21. Biochimie. 2020. PMID: 32330571
Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype.
Amenyah SD, McMahon A, Ward M, Deane J, McNulty H, Hughes CF, Strain JJ, Horigan G, Purvis J, Walsh CP, Lees-Murdock DJ. Amenyah SD, et al. Among authors: horigan g. Biochimie. 2020 Jun;173:17-26. doi: 10.1016/j.biochi.2020.04.007. Epub 2020 Apr 22. Biochimie. 2020. PMID: 32334045
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