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Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: identification of a I-cM region of common allelic loss.
Kimura M, Abe T, Sunamura M, Matsuno S, Horii A. Kimura M, et al. Among authors: horii a. Genes Chromosomes Cancer. 1996 Oct;17(2):88-93. doi: 10.1002/(SICI)1098-2264(199610)17:2<88::AID-GCC3>3.0.CO;2-X. Genes Chromosomes Cancer. 1996. PMID: 8913725
As a first step toward understanding molecular mechanisms in human pancreatic carcinogenesis, we searched for the location of tumor suppressor genes by examining loss of heterozygosity (LOH) in 44 pancreatic cancer specimens. ...Because chromosome arm 12q is a repor …
As a first step toward understanding molecular mechanisms in human pancreatic carcinogenesis, we searched for the location of tumor s …
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
Miki Y, Nishisho I, Horii A, Miyoshi Y, Utsunomiya J, Kinzler KW, Vogelstein B, Nakamura Y. Miki Y, et al. Among authors: horii a. Cancer Res. 1992 Feb 1;52(3):643-5. Cancer Res. 1992. PMID: 1310068
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer. ...This is the first report of the disruption of a tumor suppressor gen …
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) …
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
Miyoshi Y, Ando H, Nagase H, Nishisho I, Horii A, Miki Y, Mori T, Utsunomiya J, Baba S, Petersen G, et al. Miyoshi Y, et al. Among authors: horii a. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4452-6. doi: 10.1073/pnas.89.10.4452. Proc Natl Acad Sci U S A. 1992. PMID: 1316610 Free PMC article.
We searched for germ-line mutations of the APC gene in 79 unrelated patients with familial adenomatous polyposis using a ribonuclease protection analysis coupled with polymerase chain reaction amplifications of genomic DNA. ...
We searched for germ-line mutations of the APC gene in 79 unrelated patients with familial adenomatous polyposis using a ribonuclease …
The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.
Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Kato Y, Yanagisawa A, Nakamura Y. Horii A, et al. Cancer Res. 1992 Jun 1;52(11):3231-3. Cancer Res. 1992. PMID: 1317264
Based on this idea, DNAs isolated from gastric cancers were examined by means of a RNase protection analysis coupled with polymerase chain reaction followed by sequencing of the polymerase chain reaction products. By screening nearly one-half of the coding region of the AP …
Based on this idea, DNAs isolated from gastric cancers were examined by means of a RNase protection analysis coupled with polymerase …
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.
Nagase H, Miyoshi Y, Horii A, Aoki T, Ogawa M, Utsunomiya J, Baba S, Sasazuki T, Nakamura Y. Nagase H, et al. Among authors: horii a. Cancer Res. 1992 Jul 15;52(14):4055-7. Cancer Res. 1992. PMID: 1319838
Recently we have isolated the adenomatous polyposis coli (APC) gene which causes familial adenomatous polyposis (FAP), and its germ-line mutations in a substantial number of FAP patients have been identified. ...The result suggests that the number of colorectal polyps in F …
Recently we have isolated the adenomatous polyposis coli (APC) gene which causes familial adenomatous polyposis (FAP), and its germ-line mut …
Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma.
Nakatsuru S, Yanagisawa A, Ichii S, Tahara E, Kato Y, Nakamura Y, Horii A. Nakatsuru S, et al. Among authors: horii a. Hum Mol Genet. 1992 Nov;1(8):559-63. doi: 10.1093/hmg/1.8.559. Hum Mol Genet. 1992. PMID: 1338691
Eight of the 17 somatic mutations found in 12 tumors caused truncation of the gene product due to a nonsense mutation and a 1-, 2- or 5-bp deletion; nine others were point mutations that altered amino acids. Our results suggest that inactivation of APC plays a
Eight of the 17 somatic mutations found in 12 tumors caused truncation of the gene product due to a nonsense mutation and a 1- …
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y. Miyoshi Y, et al. Among authors: horii a. Hum Mol Genet. 1992 Jul;1(4):229-33. doi: 10.1093/hmg/1.4.229. Hum Mol Genet. 1992. PMID: 1338904
One tumor had a 1-bp deletion in an intron near the splicing site. Hence, 41 (95%) of 43 mutations resulted in truncation of the APC protein. ...These results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority …
One tumor had a 1-bp deletion in an intron near the splicing site. Hence, 41 (95%) of 43 mutations resulted in truncation of the APC …
Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.
Nakamura Y, Nishisho I, Kinzler KW, Vogelstein B, Miyoshi Y, Miki Y, Ando H, Horii A. Nakamura Y, et al. Among authors: horii a. Tohoku J Exp Med. 1992 Oct;168(2):141-7. doi: 10.1620/tjem.168.141. Tohoku J Exp Med. 1992. PMID: 1339098
Frequent somatic mutations of the APC gene in human pancreatic cancer.
Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Ando H, Yanagisawa A, Tsuchiya E, Kato Y, Nakamura Y. Horii A, et al. Cancer Res. 1992 Dec 1;52(23):6696-8. Cancer Res. 1992. PMID: 1423316
DNAs isolated from tumors were examined by means of a RNase protection analysis, coupled with the polymerase chain reaction followed by DNA sequencing of the polymerase chain reaction products. By screening a part of the APC coding region, we detected somatic mutati …
DNAs isolated from tumors were examined by means of a RNase protection analysis, coupled with the polymerase chain reaction followed …
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P. Nishisho I, et al. Among authors: horii a. Science. 1991 Aug 9;253(5020):665-9. doi: 10.1126/science.1651563. Science. 1991. PMID: 1651563
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