Horne VA - Search Results

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A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6.

de Groot MJ, Ackland MJ, Horne VA, Alex AA, Jones BC. de Groot MJ, et al. Among authors: horne va. J Med Chem. 1999 Oct 7;42(20):4062-70. doi: 10.1021/jm991058v. J Med Chem. 1999. PMID: 10514276

Rapid assessment of a novel series of selective CB(2) agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis.

Ryckmans T, Edwards MP, Horne VA, Correia AM, Owen DR, Thompson LR, Tran I, Tutt MF, Young T. Ryckmans T, et al. Among authors: horne va. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4406-9. doi: 10.1016/j.bmcl.2009.05.062. Epub 2009 May 21. Bioorg Med Chem Lett. 2009. PMID: 19500981

2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology.

Owen DR, Rodriguez-Lens M, Corless MD, Gaulier SM, Horne VA, Kinloch RA, Maw GN, Pearce DW, Rees H, Ringer TJ, Ryckmans T, Stammen BL. Owen DR, et al. Among authors: horne va. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1702-6. doi: 10.1016/j.bmcl.2009.01.106. Epub 2009 Feb 5. Bioorg Med Chem Lett. 2009. PMID: 19231185

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.

Barber CG, Dickinson RP, Horne VA. Barber CG, et al. Among authors: horne va. Bioorg Med Chem Lett. 2002 Jan 21;12(2):181-4. doi: 10.1016/s0960-894x(01)00701-6. Bioorg Med Chem Lett. 2002. PMID: 11755349

Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.

Fish PV, Barber CG, Brown DG, Butt R, Collis MG, Dickinson RP, Henry BT, Horne VA, Huggins JP, King E, O'Gara M, McCleverty D, McIntosh F, Phillips C, Webster R. Fish PV, et al. Among authors: horne va. J Med Chem. 2007 May 17;50(10):2341-51. doi: 10.1021/jm061066t. Epub 2007 Apr 21. J Med Chem. 2007. PMID: 17447747

Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase).

Jones BC, Hawksworth G, Horne VA, Newlands A, Morsman J, Tute MS, Smith DA. Jones BC, et al. Among authors: horne va. Drug Metab Dispos. 1996 Feb;24(2):260-6. Drug Metab Dispos. 1996. PMID: 8742240

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6.

de Groot MJ, Ackland MJ, Horne VA, Alex AA, Jones BC. de Groot MJ, et al. Among authors: horne va. J Med Chem. 1999 May 6;42(9):1515-24. doi: 10.1021/jm981118h. J Med Chem. 1999. PMID: 10229622

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