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Matrix-directed regulation of pericellular proteolysis and tumor progression.
Hornebeck W, Emonard H, Monboisse JC, Bellon G. Hornebeck W, et al. Semin Cancer Biol. 2002 Jun;12(3):231-41. doi: 10.1016/s1044-579x(02)00026-3. Semin Cancer Biol. 2002. PMID: 12083853 Review.
Elastin fragments induce IL-1beta upregulation via NF-kappaB pathway in melanoma cells.
Debret R, Le Naour RR, Sallenave JM, Deshorgue A, Hornebeck WG, Guenounou M, Bernard P, Antonicelli FD. Debret R, et al. J Invest Dermatol. 2006 Aug;126(8):1860-8. doi: 10.1038/sj.jid.5700337. Epub 2006 May 4. J Invest Dermatol. 2006. PMID: 16675961
TIMP-1 binding to proMMP-9/CD44 complex localized at the cell surface promotes erythroid cell survival.
Lambert E, Bridoux L, Devy J, Dassé E, Sowa ML, Duca L, Hornebeck W, Martiny L, Petitfrère-Charpentier E. Lambert E, et al. Among authors: hornebeck w. Int J Biochem Cell Biol. 2009 May;41(5):1102-15. doi: 10.1016/j.biocel.2008.10.017. Epub 2008 Oct 25. Int J Biochem Cell Biol. 2009. PMID: 19010442
Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer.
Thiéfin G, Dupont A, Guillou PJ, Vitry F, Bouche O, Yaziji N, Lagarde S, Maquart FX, Palot JP, Hornebeck W, Diebold MD. Thiéfin G, et al. Among authors: hornebeck w. Anticancer Res. 2007 Jan-Feb;27(1B):583-8. Anticancer Res. 2007. PMID: 17348445
Elastin-elastases and inflamm-aging.
Antonicelli F, Bellon G, Debelle L, Hornebeck W. Antonicelli F, et al. Among authors: hornebeck w. Curr Top Dev Biol. 2007;79:99-155. doi: 10.1016/S0070-2153(06)79005-6. Curr Top Dev Biol. 2007. PMID: 17498549 Review.
Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation.
Debret R, Brassart-Pasco S, Lorin J, Martoriati A, Deshorgue A, Maquart FX, Hornebeck W, Rahman I, Antonicelli F. Debret R, et al. Among authors: hornebeck w. Biochim Biophys Acta. 2008 Oct;1783(10):1718-27. doi: 10.1016/j.bbamcr.2008.06.001. Epub 2008 Jun 13. Biochim Biophys Acta. 2008. PMID: 18598724
The elastin peptides-mediated induction of pro-collagenase-1 production by human fibroblasts involves activation of MEK/ERK pathway via PKA- and PI(3)K-dependent signaling.
Duca L, Debelle L, Debret R, Antonicelli F, Hornebeck W, Haye B. Duca L, et al. Among authors: hornebeck w. FEBS Lett. 2002 Jul 31;524(1-3):193-8. doi: 10.1016/s0014-5793(02)03057-0. FEBS Lett. 2002. PMID: 12135766
Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies.
Moroy G, Denhez C, El Mourabit H, Toribio A, Dassonville A, Decarme M, Renault JH, Mirand C, Bellon G, Sapi J, Alix AJ, Hornebeck W, Bourguet E. Moroy G, et al. Among authors: hornebeck w. Bioorg Med Chem. 2007 Jul 15;15(14):4753-66. doi: 10.1016/j.bmc.2007.05.001. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17512742
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion.
Robinet A, Emonard H, Banyai L, Laronze JY, Patthy L, Hornebeck W, Bellon G. Robinet A, et al. Among authors: hornebeck w. Life Sci. 2008 Feb 13;82(7-8):376-82. doi: 10.1016/j.lfs.2007.11.018. Epub 2007 Dec 5. Life Sci. 2008. PMID: 18222489
Neutrophil elastase as a target in lung cancer.
Moroy G, Alix AJ, Sapi J, Hornebeck W, Bourguet E. Moroy G, et al. Among authors: hornebeck w. Anticancer Agents Med Chem. 2012 Jul;12(6):565-79. doi: 10.2174/187152012800617696. Anticancer Agents Med Chem. 2012. PMID: 22263788 Review.
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