Horton TM - Search Results

1

Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells.

Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Horton TM, et al. Cell Chem Biol. 2019 Feb 21;26(2):213-222.e6. doi: 10.1016/j.chembiol.2018.10.019. Epub 2018 Dec 6. Cell Chem Biol. 2019. PMID: 30527998 Free PMC article.

2

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization.

Allegretti PA, Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP. Allegretti PA, et al. Among authors: horton tm. Bioorg Med Chem. 2020 Jan 1;28(1):115193. doi: 10.1016/j.bmc.2019.115193. Epub 2019 Nov 11. Bioorg Med Chem. 2020. PMID: 31757680 Free PMC article.

3

Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas.

Horton TM, Kraemer BR, Annes JP. Horton TM, et al. STAR Protoc. 2021 Jan 12;2(1):100263. doi: 10.1016/j.xpro.2020.100263. eCollection 2021 Mar 19. STAR Protoc. 2021. PMID: 33490979 Free PMC article.

4

CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition.

Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D, Shalizi A, Smith M, Armstrong NA, Annes JP. Abdolazimi Y, et al. Among authors: horton tm. Endocrinology. 2018 Sep 1;159(9):3143-3157. doi: 10.1210/en.2018-00083. Endocrinology. 2018. PMID: 29514186 Free PMC article.

5

Novel Pathogenic De Novo INS p.T97P Variant Presenting With Severe Neonatal DKA.

Lal RA, Moeller HP, Thomson EA, Horton TM, Lee S, Freeman R, Prahalad P, Poon ASY, Annes JP. Lal RA, et al. Among authors: horton tm. Endocrinology. 2022 Feb 1;163(2):bqab246. doi: 10.1210/endocr/bqab246. Endocrinology. 2022. PMID: 34888628 Free PMC article.

6

PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker.

Horton TM, Sundaram V, Lee CH, Hornbacker K, Van Vleck A, Benjamin KN, Zemek A, Longacre TA, Kunz PL, Annes JP. Horton TM, et al. Sci Rep. 2020 Jul 2;10(1):10943. doi: 10.1038/s41598-020-68071-6. Sci Rep. 2020. PMID: 32616904 Free PMC article.

7

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Visperas PR, et al. Among authors: horton tm. Biochem J. 2015 Jan 1;465(1):149-61. doi: 10.1042/BJ20140793. Biochem J. 2015. PMID: 25287889 Free PMC article.

8

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Among authors: horton tm. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.

9

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC. Mendoza JL, et al. Among authors: horton tm. Immunity. 2017 Mar 21;46(3):379-392. doi: 10.1016/j.immuni.2017.02.017. Immunity. 2017. PMID: 28329704 Free PMC article.

10

MRD at the End of Induction and EFS in T-cell Lymphoblastic Lymphoma: Children's Oncology Group Trial AALL1231.

Hayashi RJ, Hermiston ML, Wood BL, Teachey DT, Devidas M, Chen Z, Annett RD, Asselin BL, August K, Cho S, Dunsmore KP, Freedman JL, Galardy PJ, Harker-Murray P, Horton TM, Jaju A, Lam A, Messinger YH, Miles RR, Okada M, Patel S, Schafer ES, Schechter T, Shimano KA, Singh N, Steele A, Sulis ML, Vargas S, Winter SS, Wood C, Zweider-McKay PA, Loh ML, Hunger SP, Raetz EA, Bollard CM, Allen CE. Hayashi RJ, et al. Among authors: horton tm. Blood. 2024 Mar 8:blood.2023021184. doi: 10.1182/blood.2023021184. Online ahead of print. Blood. 2024. PMID: 38457359

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