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Drug discovery targeting the chemokine system--where are we?
Horuk R, Proudfoot AE. Horuk R, et al. Front Biosci (Elite Ed). 2009 Jun 1;1:209-19. Front Biosci (Elite Ed). 2009. PMID: 19482638 Review.
Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis.
He M, Horuk R, Moochhala SM, Bhatia M. He M, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1173-80. doi: 10.1152/ajpgi.00420.2006. Epub 2007 Jan 18. Am J Physiol Gastrointest Liver Physiol. 2007. PMID: 17234893
Chemokine receptor antagonists.
Pease J, Horuk R. Pease J, et al. Among authors: horuk r. J Med Chem. 2012 Nov 26;55(22):9363-92. doi: 10.1021/jm300682j. Epub 2012 Sep 24. J Med Chem. 2012. PMID: 22931505 No abstract available.
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. Bachelerie F, et al. Among authors: horuk r. Pharmacol Rev. 2013 Nov 11;66(1):1-79. doi: 10.1124/pr.113.007724. Print 2014. Pharmacol Rev. 2013. PMID: 24218476 Free PMC article. Review.
Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor.
Rot A, McKimmie C, Burt CL, Pallas KJ, Jamieson T, Pruenster M, Horuk R, Nibbs RJB, Graham GJ. Rot A, et al. Among authors: horuk r. J Immunol. 2013 Jun 15;190(12):6450-6456. doi: 10.4049/jimmunol.1201429. Epub 2013 May 13. J Immunol. 2013. PMID: 23670187 Free PMC article.
4-Azetidinyl-1-heteroatom linked cyclohexane antagonists of CCR2: patent evaluation.
Horuk R, Guilford W. Horuk R, et al. Expert Opin Ther Pat. 2011 Aug;21(8):1275-80. doi: 10.1517/13543776.2011.584872. Epub 2011 May 10. Expert Opin Ther Pat. 2011. PMID: 21554155 Review.
Small molecule antagonists of chemokine receptors--is promiscuity a virtue?
Pease JE, Horuk R. Pease JE, et al. Curr Top Med Chem. 2010;10(13):1351-8. doi: 10.2174/156802610791561228. Curr Top Med Chem. 2010. PMID: 20536423 Review.
Chemokine receptor antagonists: Part 1.
Pease JE, Horuk R. Pease JE, et al. Expert Opin Ther Pat. 2009 Jan;19(1):39-58. doi: 10.1517/13543770802641346. Expert Opin Ther Pat. 2009. PMID: 19441897 Review.
Chemokine receptor antagonists: overcoming developmental hurdles.
Horuk R. Horuk R. Nat Rev Drug Discov. 2009 Jan;8(1):23-33. doi: 10.1038/nrd2734. Epub 2008 Dec 12. Nat Rev Drug Discov. 2009. PMID: 19079127 Review.
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