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Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.
Biochem Pharmacol. 2013 Apr 15;85(8):1091-103. doi: 10.1016/j.bcp.2013.01.029. Epub 2013 Feb 8.
Biochem Pharmacol. 2013.
PMID: 23399641
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJB, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF.
Rich MH, et al. Among authors: horvat cn.
Cell Chem Biol. 2023 Dec 21;30(12):1680-1691.e6. doi: 10.1016/j.chembiol.2023.10.001. Epub 2023 Oct 27.
Cell Chem Biol. 2023.
PMID: 37898120
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A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJ, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF.
Rich MH, et al. Among authors: horvat cn.
bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534183. doi: 10.1101/2023.03.24.534183.
bioRxiv. 2023.
PMID: 36993673
Free PMC article.
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Preprint.
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