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Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria.
Weiss J, Elsbach P, Shu C, Castillo J, Grinna L, Horwitz A, Theofan G. Weiss J, et al. Among authors: Horwitz A. J Clin Invest. 1992 Sep;90(3):1122-30. doi: 10.1172/JCI115930. J Clin Invest. 1992. PMID: 1522221 Free PMC article.
A recombinant amino terminal fragment of bactericidal/permeability-increasing protein inhibits the induction of leukocyte responses by LPS.
Mészáros K, Parent JB, Gazzano-Santoro H, Little R, Horwitz A, Parsons T, Theofan G, Grinna L, Weickmann J, Elsbach P, et al. Mészáros K, et al. Among authors: Horwitz A. J Leukoc Biol. 1993 Dec;54(6):558-63. doi: 10.1002/jlb.54.6.558. J Leukoc Biol. 1993. PMID: 8245707
High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide.
Gazzano-Santoro H, Parent JB, Grinna L, Horwitz A, Parsons T, Theofan G, Elsbach P, Weiss J, Conlon PJ. Gazzano-Santoro H, et al. Among authors: Horwitz A. Infect Immun. 1992 Nov;60(11):4754-61. Infect Immun. 1992. PMID: 1398985 Free PMC article.
Biochemical characterization of recombinant fusions of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein. Implications in biological activity.
Abrahamson SL, Wu HM, Williams RE, Der K, Ottah N, Little R, Gazzano-Santoro H, Theofan G, Bauer R, Leigh S, Orme A, Horwitz AH, Carroll SF, Dedrick RL. Abrahamson SL, et al. Among authors: Horwitz AH. J Biol Chem. 1997 Jan 24;272(4):2149-55. doi: 10.1074/jbc.272.4.2149. J Biol Chem. 1997. PMID: 8999916
Competition between rBPI23, a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria.
Gazzano-Santoro H, Mészáros K, Birr C, Carroll SF, Theofan G, Horwitz AH, Lim E, Aberle S, Kasler H, Parent JB. Gazzano-Santoro H, et al. Among authors: Horwitz AH. Infect Immun. 1994 Apr;62(4):1185-91. Infect Immun. 1994. PMID: 8132325 Free PMC article.
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