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Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. McKee AS, et al. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. doi: 10.1073/pnas.1300392110. Epub 2013 Feb 27. Proc Natl Acad Sci U S A. 2013. PMID: 23447566 Free PMC article.
Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum's functions. Host DNA rapidly coats injected alum. ...Thus, from the muscle, an immunization site that does not require host DNA to promote migratio …
Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum's functions. Host DNA …
Research Progress of Aluminum Phosphate Adjuvants and Their Action Mechanisms.
Zhang T, He P, Guo D, Chen K, Hu Z, Zou Y. Zhang T, et al. Pharmaceutics. 2023 Jun 17;15(6):1756. doi: 10.3390/pharmaceutics15061756. Pharmaceutics. 2023. PMID: 37376204 Free PMC article. Review.
Aluminum-containing adjuvants can enhance immune response through a variety of molecular pathways, but there are still significant challenges in designing effective immune-stimulating vaccine delivery systems with aluminum-containing adjuvant …
Aluminum-containing adjuvants can enhance immune response through a variety of molecular pathways, but there are …