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The role of TNFalpha and TNF receptors in obesity and insulin resistance.
Hotamisligil GS. Hotamisligil GS. J Intern Med. 1999 Jun;245(6):621-5. doi: 10.1046/j.1365-2796.1999.00490.x. J Intern Med. 1999. PMID: 10395191 Review.
Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.
Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Fu S, et al. Sci Transl Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. Sci Transl Med. 2015. PMID: 26084805 Free PMC article.
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.
Arruda AP, Hotamisligil GS. Arruda AP, et al. Cell Metab. 2015 Sep 1;22(3):381-97. doi: 10.1016/j.cmet.2015.06.010. Epub 2015 Jul 16. Cell Metab. 2015. PMID: 26190652 Free PMC article. Review.
A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.
Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS. Nakamura T, et al. Cell Rep. 2015 Apr 14;11(2):295-307. doi: 10.1016/j.celrep.2015.03.021. Epub 2015 Apr 2. Cell Rep. 2015. PMID: 25843719 Free PMC article.
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.
Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Engin F, et al. Sci Transl Med. 2013 Nov 13;5(211):211ra156. doi: 10.1126/scitranslmed.3006534. Sci Transl Med. 2013. PMID: 24225943 Free PMC article.
The role of JNK proteins in metabolism.
Vallerie SN, Hotamisligil GS. Vallerie SN, et al. Sci Transl Med. 2010 Dec 1;2(60):60rv5. doi: 10.1126/scitranslmed.3001007. Sci Transl Med. 2010. PMID: 21123811 Review.
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