Hou C - Search Results

1

Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.

Hou C, Mandal A, Rohr J, Tsodikov OV. Hou C, et al. Structure. 2021 May 6;29(5):404-412.e4. doi: 10.1016/j.str.2020.11.012. Epub 2020 Dec 3. Structure. 2021. PMID: 33275876 Free PMC article.

2

Structural insight into MtmC, a bifunctional ketoreductase-methyltransferase involved in the assembly of the mithramycin trisaccharide chain.

Chen JM, Hou C, Wang G, Tsodikov OV, Rohr J. Chen JM, et al. Among authors: hou c. Biochemistry. 2015 Apr 21;54(15):2481-9. doi: 10.1021/bi501462g. Epub 2015 Apr 7. Biochemistry. 2015. PMID: 25587924 Free PMC article.

3

Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.

Hou C, Tsodikov OV. Hou C, et al. Biochemistry. 2015 Dec 22;54(50):7365-74. doi: 10.1021/acs.biochem.5b01121. Epub 2015 Dec 10. Biochemistry. 2015. PMID: 26618620

4

Dimerization and DNA recognition rules of mithramycin and its analogues.

Weidenbach S, Hou C, Chen JM, Tsodikov OV, Rohr J. Weidenbach S, et al. Among authors: hou c. J Inorg Biochem. 2016 Mar;156:40-7. doi: 10.1016/j.jinorgbio.2015.12.011. Epub 2015 Dec 18. J Inorg Biochem. 2016. PMID: 26760230 Free PMC article.

5

Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.

Hou C, Weidenbach S, Cano KE, Wang Z, Mitra P, Ivanov DN, Rohr J, Tsodikov OV. Hou C, et al. Nucleic Acids Res. 2016 Oct 14;44(18):8990-9004. doi: 10.1093/nar/gkw761. Epub 2016 Sep 1. Nucleic Acids Res. 2016. PMID: 27587584 Free PMC article.

6

Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events.

Hou C, Biswas T, Tsodikov OV. Hou C, et al. Biochemistry. 2018 Apr 10;57(14):2084-2093. doi: 10.1021/acs.biochem.8b00036. Epub 2018 Mar 23. Biochemistry. 2018. PMID: 29558114

7

Utilizing guanine-coordinated Zn²⁺ ions to determine DNA crystal structures by single-wavelength anomalous diffraction.

Hou C, Tsodikov OV. Hou C, et al. Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):32-40. doi: 10.1107/S205979831801553X. Epub 2019 Jan 7. Acta Crystallogr D Struct Biol. 2019. PMID: 30644843

8

How mithramycin stereochemistry dictates its structure and DNA binding function.

Hou C, Rohr J, Parkin S, Tsodikov OV. Hou C, et al. Medchemcomm. 2019 Mar 28;10(5):735-741. doi: 10.1039/c9md00100j. eCollection 2019 May 1. Medchemcomm. 2019. PMID: 31191864 Free PMC article.

9

Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.

Wheeler R, Yu X, Hou C, Mitra P, Chen JM, Herkules F, Ivanov DN, Tsodikov OV, Rohr J. Wheeler R, et al. Among authors: hou c. Angew Chem Int Ed Engl. 2020 Jan 7;59(2):826-832. doi: 10.1002/anie.201910241. Epub 2019 Nov 27. Angew Chem Int Ed Engl. 2020. PMID: 31702856 Free PMC article.

10

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.

Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S. Tsodikov OV, et al. Among authors: hou c. BMC Struct Biol. 2015 Jul 15;15:13. doi: 10.1186/s12900-015-0040-6. BMC Struct Biol. 2015. PMID: 26170207 Free PMC article.

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