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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA. Fang EF, et al. Among authors: hou y. Nat Commun. 2019 Nov 21;10(1):5284. doi: 10.1038/s41467-019-13172-8. Nat Commun. 2019. PMID: 31754102 Free PMC article.
Genome instability in Alzheimer disease.
Hou Y, Song H, Croteau DL, Akbari M, Bohr VA. Hou Y, et al. Mech Ageing Dev. 2017 Jan;161(Pt A):83-94. doi: 10.1016/j.mad.2016.04.005. Epub 2016 Apr 20. Mech Ageing Dev. 2017. PMID: 27105872 Free PMC article. Review.
NAD+ in Aging: Molecular Mechanisms and Translational Implications.
Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA. Fang EF, et al. Among authors: hou y. Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Trends Mol Med. 2017. PMID: 28899755 Free PMC article. Review.
In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.
Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA. Fang EF, et al. Among authors: hou y. J Vis Exp. 2017 Nov 22;(129):56301. doi: 10.3791/56301. J Vis Exp. 2017. PMID: 29286376 Free PMC article.
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA. Hou Y, et al. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. doi: 10.1073/pnas.1718819115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432159 Free PMC article.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA. Fang EF, et al. Among authors: hou y. Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11. Nat Neurosci. 2019. PMID: 30742114 Free PMC article.
Ageing as a risk factor for neurodegenerative disease.
Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA. Hou Y, et al. Nat Rev Neurol. 2019 Oct;15(10):565-581. doi: 10.1038/s41582-019-0244-7. Epub 2019 Sep 9. Nat Rev Neurol. 2019. PMID: 31501588 Review.
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