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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.
Houghten RA, Pinilla C, Blondelle SE, Appel JR, Dooley CT, Cuervo JH. Houghten RA, et al. Nature. 1991 Nov 7;354(6348):84-6. doi: 10.1038/354084a0. Nature. 1991. PMID: 1719428
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.
Tainer JA, Getzoff ED, Alexander H, Houghten RA, Olson AJ, Lerner RA, Hendrickson WA. Tainer JA, et al. Among authors: houghten ra. Nature. 1984 Nov 8-14;312(5990):127-34. doi: 10.1038/312127a0. Nature. 1984. PMID: 6209578
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence.
Bittle JL, Houghten RA, Alexander H, Shinnick TM, Sutcliffe JG, Lerner RA, Rowlands DJ, Brown F. Bittle JL, et al. Among authors: houghten ra. Nature. 1982 Jul 1;298(5869):30-3. doi: 10.1038/298030a0. Nature. 1982. PMID: 7045684 No abstract available.
The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn.
Dyson HJ, Cross KJ, Houghten RA, Wilson IA, Wright PE, Lerner RA. Dyson HJ, et al. Among authors: houghten ra. Nature. 1985 Dec 5-11;318(6045):480-3. doi: 10.1038/318480a0. Nature. 1985. PMID: 4069219
Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries.
Blondelle SE, Takahashi E, Houghten RA, Pérez-Payá E. Blondelle SE, et al. Among authors: houghten ra. Biochem J. 1996 Jan 1;313 ( Pt 1)(Pt 1):141-7. doi: 10.1042/bj3130141. Biochem J. 1996. PMID: 8546675 Free PMC article.
Parallel array and mixture-based synthetic combinatorial chemistry: tools for the next millennium.
Houghten RA. Houghten RA. Annu Rev Pharmacol Toxicol. 2000;40:273-82. doi: 10.1146/annurev.pharmtox.40.1.273. Annu Rev Pharmacol Toxicol. 2000. PMID: 10836136 Review.
Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reaction.
Vidal A, Nefzi A, Houghten RA. Vidal A, et al. Among authors: houghten ra. J Org Chem. 2001 Nov 30;66(24):8268-72. doi: 10.1021/jo010872z. J Org Chem. 2001. PMID: 11722240 No abstract available.
Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.
Yu Y, Ostresh JM, Houghten RA. Yu Y, et al. Among authors: houghten ra. Org Lett. 2001 Sep 6;3(18):2797-9. doi: 10.1021/ol010102+. Org Lett. 2001. PMID: 11529759
Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.
Nefzi A, Giulianotti MA, Ong NA, Houghten RA. Nefzi A, et al. Among authors: houghten ra. Org Lett. 2000 Oct 19;2(21):3349-50. doi: 10.1021/ol000225e. Org Lett. 2000. PMID: 11029207
Mixture-based synthetic combinatorial libraries.
Houghten RA, Pinilla C, Appel JR, Blondelle SE, Dooley CT, Eichler J, Nefzi A, Ostresh JM. Houghten RA, et al. J Med Chem. 1999 Sep 23;42(19):3743-78. doi: 10.1021/jm990174v. J Med Chem. 1999. PMID: 10508425 Review. No abstract available.
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