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Shared pathways: death receptors and cytotoxic drugs in cancer therapy.
Peták I, Houghton JA. Peták I, et al. Among authors: houghton ja. Pathol Oncol Res. 2001;7(2):95-106. doi: 10.1007/BF03032574. Pathol Oncol Res. 2001. PMID: 11458271 Review.
Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.
Nagy K, Székely-Szüts K, Izeradjene K, Douglas L, Tillman M, Barti-Juhász H, Dominici M, Spano C, Luca Cervo G, Conte P, Houghton JA, Mihalik R, Kopper L, Peták I. Nagy K, et al. Among authors: houghton ja. Pathol Oncol Res. 2006;12(3):133-42. doi: 10.1007/BF02893359. Epub 2006 Sep 23. Pathol Oncol Res. 2006. PMID: 16998592
Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.
Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA. Izeradjene K, et al. Among authors: houghton ja. Cancer Res. 2005 Aug 15;65(16):7436-45. doi: 10.1158/0008-5472.CAN-04-2628. Cancer Res. 2005. PMID: 16103097
Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases.
Phillips DC, Martin S, Doyle BT, Houghton JA. Phillips DC, et al. Among authors: houghton ja. Cancer Res. 2007 Jan 15;67(2):756-64. doi: 10.1158/0008-5472.CAN-06-2374. Cancer Res. 2007. PMID: 17234787
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.
Carew JS, Nawrocki ST, Kahue CN, Zhang H, Yang C, Chung L, Houghton JA, Huang P, Giles FJ, Cleveland JL. Carew JS, et al. Among authors: houghton ja. Blood. 2007 Jul 1;110(1):313-22. doi: 10.1182/blood-2006-10-050260. Epub 2007 Mar 15. Blood. 2007. PMID: 17363733 Free PMC article.
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.
Bois PR, Izeradjene K, Houghton PJ, Cleveland JL, Houghton JA, Grosveld GC. Bois PR, et al. Among authors: houghton pj, houghton ja. J Cell Biol. 2005 Sep 12;170(6):903-12. doi: 10.1083/jcb.200501040. J Cell Biol. 2005. PMID: 16157701 Free PMC article. Retracted.
Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae.
Martin S, Phillips DC, Szekely-Szucs K, Elghazi L, Desmots F, Houghton JA. Martin S, et al. Among authors: houghton ja. Cancer Res. 2005 Dec 15;65(24):11447-58. doi: 10.1158/0008-5472.CAN-05-1494. Cancer Res. 2005. PMID: 16357153
The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib.
Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ, Cleveland JL. Carew JS, et al. Among authors: houghton ja. Cancer Res. 2008 Jun 15;68(12):4783-90. doi: 10.1158/0008-5472.CAN-07-6483. Cancer Res. 2008. PMID: 18559525 Free PMC article.
Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.
Nawrocki ST, Carew JS, Douglas L, Cleveland JL, Humphreys R, Houghton JA. Nawrocki ST, et al. Among authors: houghton ja. Cancer Res. 2007 Jul 15;67(14):6987-94. doi: 10.1158/0008-5472.CAN-07-0812. Cancer Res. 2007. PMID: 17638911
Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.
Izeradjene K, Douglas L, Delaney A, Houghton JA. Izeradjene K, et al. Among authors: houghton ja. Oncogene. 2005 Mar 17;24(12):2050-8. doi: 10.1038/sj.onc.1208397. Oncogene. 2005. PMID: 15688023
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