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A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1.
Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M. Johnson J, et al. Among authors: houghton m. J Virol. 2019 Oct 29;93(22):e00810-19. doi: 10.1128/JVI.00810-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462563 Free PMC article.
Hepatitis C Virus: 30 Years after Its Discovery.
Houghton M. Houghton M. Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a037069. doi: 10.1101/cshperspect.a037069. Cold Spring Harb Perspect Med. 2019. PMID: 31501269 Review.
Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins.
Akache B, Deschatelets L, Harrison BA, Dudani R, Stark FC, Jia Y, Landi A, Law JLM, Logan M, Hockman D, Kundu J, Tyrrell DL, Krishnan L, Houghton M, McCluskie MJ. Akache B, et al. Among authors: houghton m. Vaccines (Basel). 2019 Dec 3;7(4):204. doi: 10.3390/vaccines7040204. Vaccines (Basel). 2019. PMID: 31816920 Free PMC article.
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.
Santer DM, Minty GES, Golec DP, Lu J, May J, Namdar A, Shah J, Elahi S, Proud D, Joyce M, Tyrrell DL, Houghton M. Santer DM, et al. Among authors: houghton m. PLoS Pathog. 2020 Apr 30;16(4):e1008515. doi: 10.1371/journal.ppat.1008515. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32353085 Free PMC article.
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.
Hu Z, Rolt A, Hu X, Ma CD, Le DJ, Park SB, Houghton M, Southall N, Anderson DE, Talley DC, Lloyd JR, Marugan JC, Liang TJ. Hu Z, et al. Among authors: houghton m. Cell Chem Biol. 2020 Jul 16;27(7):780-792.e5. doi: 10.1016/j.chembiol.2020.04.006. Epub 2020 May 7. Cell Chem Biol. 2020. PMID: 32386595 Free PMC article.
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.
Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K. Ganesan A, et al. Among authors: houghton m. Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6. Sci Rep. 2019. PMID: 31455818 Free PMC article.
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG.
Kalyaanamoorthy S, Lamothe SM, Hou X, Moon TC, Kurata HT, Houghton M, Barakat KH. Kalyaanamoorthy S, et al. Among authors: houghton m. Sci Rep. 2020 Oct 1;10(1):16262. doi: 10.1038/s41598-020-72889-5. Sci Rep. 2020. PMID: 33004839 Free PMC article.
A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Novel Drivers of Disease Progression in Primary Sclerosing Cholangitis.
Gindin Y, Chung C, Jiang Z, Zhou JZ, Xu J, Billin A, Myers RP, Goodman Z, Landi A, Houghton M, Green RM, Levy C, Kowdley KV, Bowlus CL, Muir AJ, Trauner M. Gindin Y, et al. Among authors: houghton m. Hepatology. 2020 Aug 3. doi: 10.1002/hep.31488. Online ahead of print. Hepatology. 2020. PMID: 32745270
Racial and Ethnic Disparities in Maternal and Infant Outcomes Among Opioid-Exposed Mother-Infant Dyads in Massachusetts (2017-2019).
Peeler M, Gupta M, Melvin P, Bryant AS, Diop H, Iverson R, Callaghan K, Wachman EM, Singh R, Houghton M, Greenfield SF, Schiff DM. Peeler M, et al. Among authors: houghton m. Am J Public Health. 2020 Oct 15:e1-e9. doi: 10.2105/AJPH.2020.305888. Online ahead of print. Am J Public Health. 2020. PMID: 33058701
Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants.
Simões EAF, Forleo-Neto E, Geba GP, Kamal M, Yang F, Cicirello H, Houghton MR, Rideman R, Zhao Q, Benvin SL, Hawes A, Fuller ED, Wloga E, Pizarro JMN, Munoz FM, Rush SA, McLellan JS, Lipsich L, Stahl N, Yancopoulos GD, Weinreich DM, Kyratsous CA, Sivapalasingam S. Simões EAF, et al. Among authors: houghton mr. Clin Infect Dis. 2020 Sep 8:ciaa951. doi: 10.1093/cid/ciaa951. Online ahead of print. Clin Infect Dis. 2020. PMID: 32897368
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