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IRS-1: auditing the effectiveness of mTOR inhibitors.
Easton JB, Kurmasheva RT, Houghton PJ. Easton JB, et al. Cancer Cell. 2006 Mar;9(3):153-5. doi: 10.1016/j.ccr.2006.02.027. Cancer Cell. 2006. PMID: 16530700 Review.
Amplification of the gli gene in childhood sarcomas.
Roberts WM, Douglass EC, Peiper SC, Houghton PJ, Look AT. Roberts WM, et al. Cancer Res. 1989 Oct 1;49(19):5407-13. Cancer Res. 1989. PMID: 2766305
Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.
Houghton JA, Williams LG, de Graaf SS, Cheshire PJ, Rodman JH, Maneval DC, Wainer IW, Jadaud P, Houghton PJ. Houghton JA, et al. Cancer Res. 1990 Jun 15;50(12):3493-502. Cancer Res. 1990. PMID: 2140289
Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors.
Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T. Shinjyo T, et al. Mol Cell Biol. 2001 Feb;21(3):854-64. doi: 10.1128/MCB.21.3.854-864.2001. Mol Cell Biol. 2001. PMID: 11154272 Free PMC article.
Predicted mechanisms of resistance to mTOR inhibitors.
Kurmasheva RT, Huang S, Houghton PJ. Kurmasheva RT, et al. Br J Cancer. 2006 Oct 23;95(8):955-60. doi: 10.1038/sj.bjc.6603353. Epub 2006 Sep 5. Br J Cancer. 2006. PMID: 16953237 Free PMC article. Review.
Mechanisms of resistance to rapamycins.
Huang S, Houghton PJ. Huang S, et al. Drug Resist Updat. 2001 Dec;4(6):378-91. doi: 10.1054/drup.2002.0227. Drug Resist Updat. 2001. PMID: 12030785 Review.
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.
Brunn GJ, Hudson CC, Sekulić A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC Jr, Abraham RT. Brunn GJ, et al. Science. 1997 Jul 4;277(5322):99-101. doi: 10.1126/science.277.5322.99. Science. 1997. PMID: 9204908
Studies on the mechanism of resistance to rapamycin in human cancer cells.
Hosoi H, Dilling MB, Liu LN, Danks MK, Shikata T, Sekulic A, Abraham RT, Lawrence JC Jr, Houghton PJ. Hosoi H, et al. Mol Pharmacol. 1998 Nov;54(5):815-24. doi: 10.1124/mol.54.5.815. Mol Pharmacol. 1998. PMID: 9804616
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