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Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view.
Hallifax D, Foster JA, Houston JB. Hallifax D, et al. Among authors: houston jb. Pharm Res. 2010 Oct;27(10):2150-61. doi: 10.1007/s11095-010-0218-3. Epub 2010 Jul 27. Pharm Res. 2010. PMID: 20661765
Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus.
Tucker GT, Houston JB, Huang SM. Tucker GT, et al. Among authors: houston jb. Pharm Res. 2001 Aug;18(8):1071-80. doi: 10.1023/a:1010994022294. Pharm Res. 2001. PMID: 11587475 Review. No abstract available.
Relevance of in vitro kinetic parameters to in vivo metabolism of xenobiotics.
Houston JB. Houston JB. Toxicol In Vitro. 1994 Aug;8(4):507-12. doi: 10.1016/0887-2333(94)90002-7. Toxicol In Vitro. 1994. PMID: 20692946
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes.
Davis JD, Aarons L, Houston JB. Davis JD, et al. Among authors: houston jb. Xenobiotica. 1995 Jun;25(6):563-73. doi: 10.3109/00498259509061875. Xenobiotica. 1995. PMID: 7483657
Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance.
Stringer R, Nicklin PL, Houston JB. Stringer R, et al. Among authors: houston jb. Xenobiotica. 2008 Oct;38(10):1313-29. doi: 10.1080/00498250802446286. Xenobiotica. 2008. PMID: 18853387
The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human.
Somers GI, Bayliss MK, Houston JB. Somers GI, et al. Among authors: houston jb. Xenobiotica. 2007 Aug;37(8):855-69. doi: 10.1080/00498250701474058. Xenobiotica. 2007. PMID: 17701833
Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology.
Wood FL, Houston JB, Hallifax D. Wood FL, et al. Among authors: houston jb. Drug Metab Dispos. 2017 Nov;45(11):1178-1188. doi: 10.1124/dmd.117.077040. Epub 2017 Sep 8. Drug Metab Dispos. 2017. PMID: 28887366
Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines.
Hallifax D, Galetin A, Houston JB. Hallifax D, et al. Among authors: houston jb. Xenobiotica. 2008 Apr;38(4):353-67. doi: 10.1080/00498250701834665. Xenobiotica. 2008. PMID: 18340561
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.
Andrews J, Abd-Ellah MF, Randolph NL, Kenworthy KE, Carlile DJ, Friedberg T, Houston JB. Andrews J, et al. Among authors: houston jb. Xenobiotica. 2002 Nov;32(11):937-47. doi: 10.1080/00498250210163289. Xenobiotica. 2002. PMID: 12487724
Use of Segregated Hepatocyte Scaling Factors and Cross-Species Relationships to Resolve Clearance Dependence in the Prediction of Human Hepatic Clearance.
Hallifax D, Houston JB. Hallifax D, et al. Among authors: houston jb. Drug Metab Dispos. 2019 Mar;47(3):320-327. doi: 10.1124/dmd.118.085191. Epub 2019 Jan 4. Drug Metab Dispos. 2019. PMID: 30610004
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