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What are the main methodological problems in the estimation of placebo effects?
Hróbjartsson A. Hróbjartsson A. J Clin Epidemiol. 2002 May;55(5):430-5. doi: 10.1016/s0895-4356(01)00496-6. J Clin Epidemiol. 2002. PMID: 12007544 Review.
In both cases bias due to lack of double-blinding is a potential problem....
In both cases bias due to lack of double-blinding is a potential problem....
Guidelines for Reporting Reliability and Agreement Studies (GRRAS) were proposed.
Kottner J, Audigé L, Brorson S, Donner A, Gajewski BJ, Hróbjartsson A, Roberts C, Shoukri M, Streiner DL. Kottner J, et al. J Clin Epidemiol. 2011 Jan;64(1):96-106. doi: 10.1016/j.jclinepi.2010.03.002. Epub 2010 Jun 17. J Clin Epidemiol. 2011. PMID: 21130355
Therefore, there is a need for rigorously conducted interrater and intrarater reliability and agreement studies. Information about sample selection, study design, and statistical analysis is often incomplete. ...
Therefore, there is a need for rigorously conducted interrater and intrarater reliability and agreement studies. Information about sa …
A new classification of spin in systematic reviews and meta-analyses was developed and ranked according to the severity.
Yavchitz A, Ravaud P, Altman DG, Moher D, Hrobjartsson A, Lasserson T, Boutron I. Yavchitz A, et al. J Clin Epidemiol. 2016 Jul;75:56-65. doi: 10.1016/j.jclinepi.2016.01.020. Epub 2016 Feb 2. J Clin Epidemiol. 2016. PMID: 26845744
., a description that overstates efficacy and/or understates harm) in systematic reviews and (2) rank spin in abstracts of systematic reviews according to their severity (i.e., the likelihood of distorting readers' interpretation of the results). STUDY DESIGN: First, we us …
., a description that overstates efficacy and/or understates harm) in systematic reviews and (2) rank spin in abstracts of systematic …
[Johannes Fibiger and the controlled clinical trial].
Hróbjartsson A. Hróbjartsson A. Ugeskr Laeger. 2007 Aug 27;169(35):2876. Ugeskr Laeger. 2007. PMID: 17877984 Danish. No abstract available.
Re: "A note on unmasking" (Letter commenting on: J Clin Epidemiol. 2014;67:1059-69).
Bello S, Hróbjartsson A. Bello S, et al. J Clin Epidemiol. 2016 Jan;69:265. doi: 10.1016/j.jclinepi.2015.05.031. Epub 2015 Jun 10. J Clin Epidemiol. 2016. PMID: 26154845 No abstract available.
Active placebo control groups of pharmacological interventions were rarely used but merited serious consideration: a methodological overview.
Jensen JS, Bielefeldt AØ, Hróbjartsson A. Jensen JS, et al. J Clin Epidemiol. 2017 Jul;87:35-46. doi: 10.1016/j.jclinepi.2017.03.001. Epub 2017 Mar 22. J Clin Epidemiol. 2017. PMID: 28342907 Review.
We wanted to assess how often randomized clinical drug trials use active placebo control groups; to provide a catalog, and a characterization, of such trials; and to analyze methodological arguments for and against the use of active placebo. ...In a systemati …
We wanted to assess how often randomized clinical drug trials use active placebo control groups; to provide a catalog, and a c …
Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study.
Maund E, Tendal B, Hróbjartsson A, Lundh A, Gøtzsche PC. Maund E, et al. BMJ. 2014 Jun 4;348:g3555. doi: 10.1136/bmj.g3555. BMJ. 2014. PMID: 24899651 Free PMC article.
RESULTS: Six trials used the medical coding dictionary COSTART (Coding Symbols for a Thesaurus of Adverse Reaction Terms) and three used MedDRA (Medical Dictionary for Regulatory Activities). ...In clinical study reports, the listings of adverse events for individual patie …
RESULTS: Six trials used the medical coding dictionary COSTART (Coding Symbols for a Thesaurus of Adverse Reaction Terms) and three u …
Conflicts of interest at medical journals: the influence of industry-supported randomised trials on journal impact factors and revenue - cohort study.
Lundh A, Barbateskovic M, Hróbjartsson A, Gøtzsche PC. Lundh A, et al. PLoS Med. 2010 Oct 26;7(10):e1000354. doi: 10.1371/journal.pmed.1000354. PLoS Med. 2010. PMID: 21048986 Free PMC article.
Publication of large industry-supported trials may generate many citations and journal income through reprint sales and thereby be a source of conflicts of interest for journals. ...Using Web of Science, we investigated citations of industry-supported trials and the influe …
Publication of large industry-supported trials may generate many citations and journal income through reprint sales and thereby be a
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