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Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment.
Hróbjartsson A, Gøtzsche PC. Hróbjartsson A, et al. J Intern Med. 2004 Aug;256(2):91-100. doi: 10.1111/j.1365-2796.2004.01355.x. J Intern Med. 2004. PMID: 15257721 Review.
We could not confirm this in a systematic review of 114 randomized trials that compared placebo-treated with untreated patients. ...CONCLUSION: We found no evidence of a generally large effect of placebo interventions. A possible small effect on patient-repor …
We could not confirm this in a systematic review of 114 randomized trials that compared placebo-treated with untreated patients. ...C …
The uncontrollable placebo effect.
Hróbjartsson A. Hróbjartsson A. Eur J Clin Pharmacol. 1996;50(5):345-8. doi: 10.1007/s002280050120. Eur J Clin Pharmacol. 1996. PMID: 8839653 Review.
METHODS: A theoretical methodological analysis. RESULTS: At least with present trial designs, it is impossible, with certainty, to exclude a potential placebo effect from the so-called control group. ...CONCLUSION: I suggest that the notions of control group and pla …
METHODS: A theoretical methodological analysis. RESULTS: At least with present trial designs, it is impossible, with certainty, to ex …
Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment.
Hróbjartsson A, Gøtzsche PC. Hróbjartsson A, et al. N Engl J Med. 2001 May 24;344(21):1594-602. doi: 10.1056/NEJM200105243442106. N Engl J Med. 2001. PMID: 11372012 Review.
A placebo could be pharmacologic (e.g., a tablet), physical (e.g., a manipulation), or psychological (e.g., a conversation). ...This corresponded to a reduction in the intensity of pain of 6.5 mm on a 100-mm visual-analogue scale. CONCLUS
A placebo could be pharmacologic (e.g., a tablet), physical (e.g., a manipulation), or psychological (e.g., a co
[What is the effect of placebo interventions? A systematic review of randomized clinical trials with placebo treated and untreated patients].
Hróbjartsson A, Gøtzsche PC. Hróbjartsson A, et al. Ugeskr Laeger. 2002 Jan 14;164(3):329-33. Ugeskr Laeger. 2002. PMID: 11816328 Danish.
A placebo intervention could be pharmacological (for instance, a tablet), physical (for instance manipulation), or psychological (for instance conversation). ...In trials involving the treatment of pain, placebo was reported to have a moderate beneficial effe
A placebo intervention could be pharmacological (for instance, a tablet), physical (for instance manipulation), or psychologic
What are the main methodological problems in the estimation of placebo effects?
Hróbjartsson A. Hróbjartsson A. J Clin Epidemiol. 2002 May;55(5):430-5. doi: 10.1016/s0895-4356(01)00496-6. J Clin Epidemiol. 2002. PMID: 12007544 Review.
In both cases bias due to lack of double-blinding is a potential problem....
In both cases bias due to lack of double-blinding is a potential problem....
Placebo treatment versus no treatment.
Hróbjartsson A, Gøtzsche PC. Hróbjartsson A, et al. Cochrane Database Syst Rev. 2003;(1):CD003974. doi: 10.1002/14651858.CD003974. Cochrane Database Syst Rev. 2003. PMID: 12535498 Updated. Review.
SELECTION CRITERIA: Randomised placebo trials with a no-treatment control group investigating any health problem were included. ...There was a modest apparent analgesic effect of placebo interventions, standardised mean difference -0.27 (-0.40 to -0.15), but also …
SELECTION CRITERIA: Randomised placebo trials with a no-treatment control group investigating any health problem were included. ...Th …
The use of placebo interventions in medical practice--a national questionnaire survey of Danish clinicians.
Hróbjartsson A, Norup M. Hróbjartsson A, et al. Eval Health Prof. 2003 Jun;26(2):153-65. doi: 10.1177/0163278703026002002. Eval Health Prof. 2003. PMID: 12789709
The authors sent a questionnaire to 772 randomly selected Danish clinicians and asked them about their use of placebo interventions. ...The most important reason for the use of placebo interventions was to avoid a confrontation with the patient. Typical placebos wer …
The authors sent a questionnaire to 772 randomly selected Danish clinicians and asked them about their use of placebo interventions. …
Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles.
Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG. Chan AW, et al. JAMA. 2004 May 26;291(20):2457-65. doi: 10.1001/jama.291.20.2457. JAMA. 2004. PMID: 15161896
The number and characteristics of reported and unreported trial outcomes were recorded from protocols, journal articles, and a survey of trialists. ...Statistically significant outcomes had a higher odds of being fully reported compared with nonsignificant outcomes …
The number and characteristics of reported and unreported trial outcomes were recorded from protocols, journal articles, and a survey …
Placebo interventions for all clinical conditions.
Hróbjartsson A, Gøtzsche PC. Hróbjartsson A, et al. Cochrane Database Syst Rev. 2004;(3):CD003974. doi: 10.1002/14651858.CD003974.pub2. Cochrane Database Syst Rev. 2004. PMID: 15266510 Updated. Review.
SELECTION CRITERIA: We included randomised placebo trials with a no-treatment control group investigating any health problem. ...A possible small effect on continuous patient-reported outcomes, especially pain, could not be clearly distinguished from bias....
SELECTION CRITERIA: We included randomised placebo trials with a no-treatment control group investigating any health problem. ...A
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