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Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.
Catanzaro E, Seghetti F, Calcabrini C, Rampa A, Gobbi S, Sestili P, Turrini E, Maffei F, Hrelia P, Bisi A, Belluti F, Fimognari C. Catanzaro E, et al. Bioorg Chem. 2019 May;86:538-549. doi: 10.1016/j.bioorg.2019.02.017. Epub 2019 Feb 10. Bioorg Chem. 2019. PMID: 30782572
Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease.
Sita G, Hrelia P, Tarozzi A, Morroni F. Sita G, et al. Int J Mol Sci. 2016 Sep 1;17(9):1454. doi: 10.3390/ijms17091454. Int J Mol Sci. 2016. PMID: 27598127 Free PMC article. Review.
Micronucleus formation and induction of apoptosis by different isothiocyanates and a mixture of isothiocyanates in human lymphocyte cultures.
Fimognari C, Berti F, Iori R, Cantelli-Forti G, Hrelia P. Fimognari C, et al. Mutat Res. 2005 Apr 4;582(1-2):1-10. doi: 10.1016/j.mrgentox.2004.11.019. Epub 2005 Jan 18. Mutat Res. 2005. PMID: 15781204
Moreover, sulforaphane induced a dose-dependent increase in the number of apoptotic cells, which was significant at the highest concentration tested (30 microM) (41% versus 18% in the untreated samples, P<0.05). ...In fact, the mixture of ITCs was able to induce a dose- …
Moreover, sulforaphane induced a dose-dependent increase in the number of apoptotic cells, which was significant at the highest concentratio …
Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
Morroni F, Sita G, Djemil A, D'Amico M, Pruccoli L, Cantelli-Forti G, Hrelia P, Tarozzi A. Morroni F, et al. J Agric Food Chem. 2018 Jan 31;66(4):856-865. doi: 10.1021/acs.jafc.7b04641. Epub 2018 Jan 22. J Agric Food Chem. 2018. PMID: 29307179

The pretreatment of SH-SY5Y cells with SFN recorded a higher (p < 0.05) active nuclear Nrf2 protein (12.0 ± 0.4 vs 8.0 ± 0.2 fold increase), mRNA Nrf2 (2.0 ± 0.3 vs 1.4 ± 0.1 fold increase), total GSH (384.0 ± 9.0 vs 256.0 ± 8.0 μM) levels, and resistance to neuronal ap

The pretreatment of SH-SY5Y cells with SFN recorded a higher (p < 0.05) active nuclear Nrf2 protein (12.0 ± 0.4 vs 8.0 ± 0.2 fold

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease.
Morroni F, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P. Morroni F, et al. Neurotoxicology. 2013 May;36:63-71. doi: 10.1016/j.neuro.2013.03.004. Epub 2013 Mar 18. Neurotoxicology. 2013. PMID: 23518299
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