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Antiviral options for biodefense.
Byrd CM, Grosenbach DW, Hruby DE. Byrd CM, et al. Among authors: hruby de. Curr Opin Virol. 2013 Oct;3(5):537-41. doi: 10.1016/j.coviro.2013.05.020. Epub 2013 Jun 15. Curr Opin Virol. 2013. PMID: 23773331 Review.
Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW. Berhanu A, et al. Among authors: hruby de. Antimicrob Agents Chemother. 2015 Jul;59(7):4296-300. doi: 10.1128/AAC.00208-15. Epub 2015 Apr 20. Antimicrob Agents Chemother. 2015. PMID: 25896687 Free PMC article.
Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Chinsangaram J, Honeychurch KM, Tyavanagimatt SR, Leeds JM, Bolken TC, Jones KF, Jordan R, Marbury T, Ruckle J, Mee-Lee D, Ross E, Lichtenstein I, Pickens M, Corrado M, Clarke JM, Frimm AM, Hruby DE. Chinsangaram J, et al. Among authors: hruby de. Antimicrob Agents Chemother. 2012 Sep;56(9):4900-5. doi: 10.1128/AAC.00904-12. Epub 2012 Jul 9. Antimicrob Agents Chemother. 2012. PMID: 22777041 Free PMC article. Clinical Trial.
New class of orthopoxvirus antiviral drugs that block viral maturation.
Byrd CM, Bolken TC, Mjalli AM, Arimilli MN, Andrews RC, Rothlein R, Andrea T, Rao M, Owens KL, Hruby DE. Byrd CM, et al. Among authors: hruby de. J Virol. 2004 Nov;78(22):12147-56. doi: 10.1128/JVI.78.22.12147-12156.2004. J Virol. 2004. PMID: 15507601 Free PMC article.
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