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An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.
Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. Hsieh CS, et al. Nat Immunol. 2006 Apr;7(4):401-10. doi: 10.1038/ni1318. Epub 2006 Mar 12. Nat Immunol. 2006. PMID: 16532000
A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation.
Hsieh CS, deRoos P, Honey K, Beers C, Rudensky AY. Hsieh CS, et al. J Immunol. 2002 Mar 15;168(6):2618-25. doi: 10.4049/jimmunol.168.6.2618. J Immunol. 2002. PMID: 11884425
The cysteinal lysosomal proteases, cathepsin L (CL) and cathepsin S (CS), have been shown to process invariant chain, thereby facilitating MHC class II maturation. ...To examine this issue, we generated embryonic fibroblast lines that express CL, CS, or neither. Exp …
The cysteinal lysosomal proteases, cathepsin L (CL) and cathepsin S (CS), have been shown to process invariant chain, thereby facilit …
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.
Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. Hsieh CS, et al. Immunity. 2004 Aug;21(2):267-77. doi: 10.1016/j.immuni.2004.07.009. Immunity. 2004. PMID: 15308106
Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins.
Bui JD, Uppaluri R, Hsieh CS, Schreiber RD. Bui JD, et al. Among authors: hsieh cs. Cancer Res. 2006 Jul 15;66(14):7301-9. doi: 10.1158/0008-5472.CAN-06-0556. Cancer Res. 2006. PMID: 16849580
A two-step process for thymic regulatory T cell development.
Lio CW, Hsieh CS. Lio CW, et al. Among authors: hsieh cs. Immunity. 2008 Jan;28(1):100-11. doi: 10.1016/j.immuni.2007.11.021. Immunity. 2008. PMID: 18199417 Free PMC article.
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.
Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA. Burchill MA, et al. Among authors: hsieh cs. Immunity. 2008 Jan;28(1):112-21. doi: 10.1016/j.immuni.2007.11.022. Immunity. 2008. PMID: 18199418 Free PMC article.
Antigen-specific peripheral shaping of the natural regulatory T cell population.
Lathrop SK, Santacruz NA, Pham D, Luo J, Hsieh CS. Lathrop SK, et al. Among authors: hsieh cs. J Exp Med. 2008 Dec 22;205(13):3105-17. doi: 10.1084/jem.20081359. Epub 2008 Dec 8. J Exp Med. 2008. PMID: 19064700 Free PMC article.
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer.
Tan MC, Goedegebuure PS, Belt BA, Flaherty B, Sankpal N, Gillanders WE, Eberlein TJ, Hsieh CS, Linehan DC. Tan MC, et al. Among authors: hsieh cs. J Immunol. 2009 Feb 1;182(3):1746-55. doi: 10.4049/jimmunol.182.3.1746. J Immunol. 2009. PMID: 19155524 Free PMC article.
Intraclonal competition limits the fate determination of regulatory T cells in the thymus.
Bautista JL, Lio CW, Lathrop SK, Forbush K, Liang Y, Luo J, Rudensky AY, Hsieh CS. Bautista JL, et al. Among authors: hsieh cs. Nat Immunol. 2009 Jun;10(6):610-7. doi: 10.1038/ni.1739. Nat Immunol. 2009. PMID: 19430476 Free PMC article.
Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset.
Lee HM, Hsieh CS. Lee HM, et al. Among authors: hsieh cs. J Immunol. 2009 Aug 15;183(4):2261-6. doi: 10.4049/jimmunol.0901304. Epub 2009 Jul 20. J Immunol. 2009. PMID: 19620303 Free PMC article.
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