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Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers.
Roshan-Moniri M, Hsing M, Butler MS, Cherkasov A, Rennie PS. Roshan-Moniri M, et al. Cancer Treat Rev. 2014 Dec;40(10):1137-52. doi: 10.1016/j.ctrv.2014.10.005. Cancer Treat Rev. 2014. PMID: 25455729 Review.
Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery.
Gentile F, Agrawal V, Hsing M, Ton AT, Ban F, Norinder U, Gleave ME, Cherkasov A. Gentile F, et al. Among authors: hsing m. ACS Cent Sci. 2020 Jun 24;6(6):939-949. doi: 10.1021/acscentsci.0c00229. Epub 2020 May 19. ACS Cent Sci. 2020. PMID: 32607441 Free PMC article.
Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.
Dalal K, Roshan-Moniri M, Sharma A, Li H, Ban F, Hassona MD, Hsing M, Singh K, LeBlanc E, Dehm S, Tomlinson Guns ES, Cherkasov A, Rennie PS. Dalal K, et al. J Biol Chem. 2014 Sep 19;289(38):26417-29. doi: 10.1074/jbc.M114.553818. Epub 2014 Aug 1. J Biol Chem. 2014. PMID: 25086042 Free PMC article.
Identification of a potent antiandrogen that targets the BF3 site of the androgen receptor and inhibits enzalutamide-resistant prostate cancer.
Munuganti RS, Hassona MD, Leblanc E, Frewin K, Singh K, Ma D, Ban F, Hsing M, Adomat H, Lallous N, Andre C, Jonadass JP, Zoubeidi A, Young RN, Guns ET, Rennie PS, Cherkasov A. Munuganti RS, et al. Chem Biol. 2014 Nov 20;21(11):1476-85. doi: 10.1016/j.chembiol.2014.09.012. Chem Biol. 2014. PMID: 25459660
Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.
Dalal K, Roshan-Moniri M, Sharma A, Li H, Ban F, Hassona MD, Hsing M, Singh K, LeBlanc E, Dehm S, Tomlinson Guns ES, Cherkasov A, Rennie PS. Dalal K, et al. J Biol Chem. 2015 Oct 23;290(43):25850. doi: 10.1074/jbc.A115.553818. J Biol Chem. 2015. PMID: 26500294 Free PMC article. No abstract available.
Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.
Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, Lawn S, Gleave ME, Gregory-Evans CY, McIntosh LP, Cox ME, Rennie PS, Cherkasov A. Butler MS, et al. Among authors: hsing m. Oncotarget. 2017 Jun 27;8(26):42438-42454. doi: 10.18632/oncotarget.17124. Oncotarget. 2017. PMID: 28465491 Free PMC article.
Relationship between insertion/deletion (indel) frequency of proteins and essentiality.
Chan SK, Hsing M, Hormozdiari F, Cherkasov A. Chan SK, et al. BMC Bioinformatics. 2007 Jun 28;8:227. doi: 10.1186/1471-2105-8-227. BMC Bioinformatics. 2007. PMID: 17598914 Free PMC article.
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE. Zoraghi R, et al. Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357306 Free PMC article.
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.
Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A. Axerio-Cilies P, et al. ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576. Epub 2011 Nov 21. ACS Chem Biol. 2012. PMID: 22066782
The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV).
Burian J, Yim G, Hsing M, Axerio-Cilies P, Cherkasov A, Spiegelman GB, Thompson CJ. Burian J, et al. Nucleic Acids Res. 2013 Dec;41(22):10062-76. doi: 10.1093/nar/gkt751. Epub 2013 Aug 28. Nucleic Acids Res. 2013. PMID: 23990327 Free PMC article.
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