Hsu KL - Search Results

1

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007. doi: 10.1038/nchembio.1105. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103940 Free PMC article.

2

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.

Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Adibekian A, et al. Among authors: hsu kl. Nat Chem Biol. 2011 May 15;7(7):469-78. doi: 10.1038/nchembio.579. Nat Chem Biol. 2011. PMID: 21572424 Free PMC article.

3

Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.

Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. Zuhl AM, et al. Among authors: hsu kl. J Am Chem Soc. 2012 Mar 21;134(11):5068-71. doi: 10.1021/ja300799t. Epub 2012 Mar 8. J Am Chem Soc. 2012. PMID: 22400490 Free PMC article.

4

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes.

Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Adibekian A, et al. Among authors: hsu kl. J Am Chem Soc. 2012 Jun 27;134(25):10345-8. doi: 10.1021/ja303400u. Epub 2012 Jun 12. J Am Chem Soc. 2012. PMID: 22690931 Free PMC article.

5

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).

Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Nagano JM, et al. Among authors: hsu kl. Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061. Epub 2012 Dec 2. Bioorg Med Chem Lett. 2013. PMID: 23260346 Free PMC article.

6

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.

Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Hsu KL, et al. J Med Chem. 2013 Nov 14;56(21):8257-69. doi: 10.1021/jm400898x. Epub 2013 Oct 23. J Med Chem. 2013. PMID: 24152245 Free PMC article.

7

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Hsu KL, et al. J Med Chem. 2013 Nov 14;56(21):8270-9. doi: 10.1021/jm400899c. Epub 2013 Oct 23. J Med Chem. 2013. PMID: 24152295 Free PMC article.

8

Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.

Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Yun B, et al. Among authors: hsu kl. J Biol Chem. 2014 Jan 17;289(3):1491-504. doi: 10.1074/jbc.M113.497651. Epub 2013 Dec 2. J Biol Chem. 2014. PMID: 24297180 Free PMC article.

9

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.

Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. Dominguez E, et al. Among authors: hsu kl. Nat Chem Biol. 2014 Feb;10(2):113-21. doi: 10.1038/nchembio.1429. Epub 2013 Dec 22. Nat Chem Biol. 2014. PMID: 24362705 Free PMC article.

10

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.

Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs W, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N. Naydenov AV, et al. Among authors: hsu kl. Neuron. 2014 Jul 16;83(2):361-371. doi: 10.1016/j.neuron.2014.06.030. Neuron. 2014. PMID: 25033180 Free PMC article.

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