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Development and applications of CRISPR-Cas9 for genome engineering.
Hsu PD, Lander ES, Zhang F. Hsu PD, et al. Cell. 2014 Jun 5;157(6):1262-1278. doi: 10.1016/j.cell.2014.05.010. Cell. 2014. PMID: 24906146 Free PMC article. Review.
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.
Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F. Konermann S, et al. Among authors: hsu pd. Nature. 2015 Jan 29;517(7536):583-8. doi: 10.1038/nature14136. Epub 2014 Dec 10. Nature. 2015. PMID: 25494202 Free PMC article.
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells.
Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA. Wu X, et al. Among authors: hsu pd. Nat Biotechnol. 2014 Jul;32(7):670-6. doi: 10.1038/nbt.2889. Epub 2014 Apr 20. Nat Biotechnol. 2014. PMID: 24752079 Free PMC article.
RNA-guided genome editing of mammalian cells.
Pyzocha NK, Ran FA, Hsu PD, Zhang F. Pyzocha NK, et al. Among authors: hsu pd. Methods Mol Biol. 2014;1114:269-77. doi: 10.1007/978-1-62703-761-7_17. Methods Mol Biol. 2014. PMID: 24557909
Crystal structure of Cas9 in complex with guide RNA and target DNA.
Nishimasu H, Ran FA, Hsu PD, Konermann S, Shehata SI, Dohmae N, Ishitani R, Zhang F, Nureki O. Nishimasu H, et al. Among authors: hsu pd. Cell. 2014 Feb 27;156(5):935-49. doi: 10.1016/j.cell.2014.02.001. Epub 2014 Feb 13. Cell. 2014. PMID: 24529477 Free PMC article.
Genome engineering using the CRISPR-Cas9 system.
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F. Ran FA, et al. Among authors: hsu pd. Nat Protoc. 2013 Nov;8(11):2281-2308. doi: 10.1038/nprot.2013.143. Epub 2013 Oct 24. Nat Protoc. 2013. PMID: 24157548 Free PMC article.
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.
Ran FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang Y, Zhang F. Ran FA, et al. Among authors: hsu pd. Cell. 2013 Sep 12;154(6):1380-9. doi: 10.1016/j.cell.2013.08.021. Epub 2013 Aug 29. Cell. 2013. PMID: 23992846 Free PMC article.
Optical control of mammalian endogenous transcription and epigenetic states.
Konermann S, Brigham MD, Trevino A, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F. Konermann S, et al. Among authors: hsu pd. Nature. 2013 Aug 22;500(7463):472-476. doi: 10.1038/nature12466. Epub 2013 Aug 23. Nature. 2013. PMID: 23877069 Free PMC article.
DNA targeting specificity of RNA-guided Cas9 nucleases.
Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F. Hsu PD, et al. Nat Biotechnol. 2013 Sep;31(9):827-32. doi: 10.1038/nbt.2647. Epub 2013 Jul 21. Nat Biotechnol. 2013. PMID: 23873081 Free PMC article.
Dissecting neural function using targeted genome engineering technologies.
Hsu PD, Zhang F. Hsu PD, et al. ACS Chem Neurosci. 2012 Aug 15;3(8):603-10. doi: 10.1021/cn300089k. Epub 2012 Jul 19. ACS Chem Neurosci. 2012. PMID: 22896804 Free PMC article. Review.
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