High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.
Wang M, Hu J, Yan L, Yang Y, He M, Wu M, Li Q, Gong W, Yang Y, Wang Y, Handy DE, Lu B, Hao C, Wang Q, Li Y, Hu R, Stanton RC, Zhang Z.
Wang M, et al. Among authors: hu j, hu r.
FASEB J. 2019 May;33(5):6296-6310. doi: 10.1096/fj.201801921R. Epub 2019 Feb 20.
FASEB J. 2019.
PMID: 30785802
In summary, our data suggest that high glucose induces ubiquitination of G6PD by VHL E3 ubiquitin ligase, which leads to ROS accumulation and podocyte injury.-Wang, M., Hu, J., Yan, L., Yang, Y., He, M., Wu, M., Li, Q., Gong, W., Yang, Y., Wang, Y., Handy, D. E., Lu …
In summary, our data suggest that high glucose induces ubiquitination of G6PD by VHL E3 ubiquitin ligase, which leads to ROS accumulation an …