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Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection.
Munson P, Liu Y, Bratt D, Fuller JT, Hu X, Pavlakis GN, Felber BK, Mullins JI, Fuller DH. Munson P, et al. Among authors: hu x. Hum Vaccin Immunother. 2018 Jul 3;14(7):1820-1831. doi: 10.1080/21645515.2018.1448328. Epub 2018 Apr 12. Hum Vaccin Immunother. 2018. PMID: 29648490 Free PMC article.
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques.
Mothe B, Hu X, Llano A, Rosati M, Olvera A, Kulkarni V, Valentin A, Alicea C, Pilkington GR, Sardesai NY, Rocafort M, Crespo M, Carrillo J, Marco A, Mullins JI, Dorrell L, Hanke T, Clotet B, Pavlakis GN, Felber BK, Brander C. Mothe B, et al. Among authors: hu x. J Transl Med. 2015 Feb 15;13:60. doi: 10.1186/s12967-015-0392-5. J Transl Med. 2015. PMID: 25879820 Free PMC article.
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV.
Hu X, Valentin A, Dayton F, Kulkarni V, Alicea C, Rosati M, Chowdhury B, Gautam R, Broderick KE, Sardesai NY, Martin MA, Mullins JI, Pavlakis GN, Felber BK. Hu X, et al. J Immunol. 2016 Nov 15;197(10):3999-4013. doi: 10.4049/jimmunol.1600697. Epub 2016 Oct 12. J Immunol. 2016. PMID: 27733554 Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Ng SSM, Nagy BA, Jensen SM, Hu X, Alicea C, Fox BA, Felber BK, Bergamaschi C, Pavlakis GN. Ng SSM, et al. Among authors: hu x. Clin Cancer Res. 2017 Jun 1;23(11):2817-2830. doi: 10.1158/1078-0432.CCR-16-1808. Epub 2016 Dec 16. Clin Cancer Res. 2017. PMID: 27986749 Free PMC article.
HIV Env conserved element DNA vaccine alters immunodominance in macaques.
Hu X, Valentin A, Rosati M, Manocheewa S, Alicea C, Chowdhury B, Bear J, Broderick KE, Sardesai NY, Gall SL, Mullins JI, Pavlakis GN, Felber BK. Hu X, et al. Hum Vaccin Immunother. 2017 Dec 2;13(12):2859-2871. doi: 10.1080/21645515.2017.1339852. Epub 2017 Jul 5. Hum Vaccin Immunother. 2017. PMID: 28678607 Free PMC article.
Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.
Singh S, Ramírez-Salazar EG, Doueiri R, Valentin A, Rosati M, Hu X, Keele BF, Shen X, Tomaras GD, Ferrari G, LaBranche C, Montefiori DC, Das J, Alter G, Trinh HV, Hamlin C, Rao M, Dayton F, Bear J, Chowdhury B, Alicea C, Lifson JD, Broderick KE, Sardesai NY, Sivananthan SJ, Fox CB, Reed SG, Venzon DJ, Hirsch VM, Pavlakis GN, Felber BK. Singh S, et al. Among authors: hu x. J Virol. 2018 Jul 17;92(15):e00281-18. doi: 10.1128/JVI.00281-18. Print 2018 Aug 1. J Virol. 2018. PMID: 29793957 Free PMC article.
DNA Vaccine-Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination.
Hu X, Valentin A, Cai Y, Dayton F, Rosati M, Ramírez-Salazar EG, Kulkarni V, Broderick KE, Sardesai NY, Wyatt LS, Earl PL, Moss B, Mullins JI, Pavlakis GN, Felber BK. Hu X, et al. Hum Gene Ther. 2018 Sep;29(9):1029-1043. doi: 10.1089/hum.2018.065. Epub 2018 Jun 21. Hum Gene Ther. 2018. PMID: 29869530 Free PMC article.
Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Hu X, Lu Z, Valentin A, Rosati M, Broderick KE, Sardesai NY, Marx PA, Mullins JI, Pavlakis GN, Felber BK. Hu X, et al. Hum Vaccin Immunother. 2018;14(9):2163-2177. doi: 10.1080/21645515.2018.1489949. Epub 2018 Jul 12. Hum Vaccin Immunother. 2018. PMID: 29939820 Free PMC article.
Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.
Felber BK, Lu Z, Hu X, Valentin A, Rosati M, Remmel CAL, Weiner JA, Carpenter MC, Faircloth K, Stanfield-Oakley S, Williams WB, Shen X, Tomaras GD, LaBranche CC, Montefiori D, Trinh HV, Rao M, Alam MS, Vandergrift NA, Saunders KO, Wang Y, Rountree W, Das J, Alter G, Reed SG, Aye PP, Schiro F, Pahar B, Dufour JP, Veazey RS, Marx PA, Venzon DJ, Shaw GM, Ferrari G, Ackerman ME, Haynes BF, Pavlakis GN. Felber BK, et al. Among authors: hu x. Cell Rep. 2020 May 12;31(6):107624. doi: 10.1016/j.celrep.2020.107624. Cell Rep. 2020. PMID: 32402293 Free PMC article.
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