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De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. Deuse T, et al. Among authors: hu x. Nat Biotechnol. 2019 Oct;37(10):1137-1144. doi: 10.1038/s41587-019-0227-7. Epub 2019 Aug 19. Nat Biotechnol. 2019. PMID: 31427818
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. Deuse T, et al. Among authors: hu x. Cell Stem Cell. 2015 Jan 8;16(1):33-8. doi: 10.1016/j.stem.2014.11.003. Epub 2014 Nov 20. Cell Stem Cell. 2015. PMID: 25465116 Free article.
The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S. Hu X, et al. Stem Cells Dev. 2020 Sep 15;29(18):1179-1189. doi: 10.1089/scd.2019.0299. Epub 2020 Aug 25. Stem Cells Dev. 2020. PMID: 32723003 Free PMC article.
The SIRPα-CD47 immune checkpoint in NK cells.
Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S. Deuse T, et al. Among authors: hu x. J Exp Med. 2021 Mar 1;218(3):e20200839. doi: 10.1084/jem.20200839. J Exp Med. 2021. PMID: 33416832 Free PMC article.
Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S. Deuse T, et al. Among authors: hu x. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2022091118. doi: 10.1073/pnas.2022091118. Proc Natl Acad Sci U S A. 2021. PMID: 34244428 Free PMC article.
Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S. Hu X, et al. Nat Commun. 2023 Apr 10;14(1):2020. doi: 10.1038/s41467-023-37785-2. Nat Commun. 2023. PMID: 37037829 Free PMC article.
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